A palladium-catalyzed cyclization reaction of phenols with trifluoromethyl-containing -bromo-β-chlorostyrenes has been developed. In the presence of palladium(II) acetate, tricyclohexylphosphine, and cesium carbonate, a variety of 6-trifluoromethyldibenzo[,]oxepines were prepared in moderate to good yields through the tandem O-alkenylation of general phenols and subsequent C-H arylation.
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| http://dx.doi.org/10.1021/acs.joc.3c01770 | DOI Listing |
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