AI Article Synopsis
- Gastric cancer (GC) is a widespread and deadly cancer, with long noncoding RNAs (lncRNAs) playing a role in its development.
- MALAT1 is a well-researched lncRNA that influences gene expression, contributing to cancer progression by interacting with microRNAs and proteins.
- The review discusses MALAT1's molecular mechanisms in GC and explores its potential as a biomarker, especially for use in non-invasive liquid biopsies.
Article Abstract
Gastric cancer (GC) remains among the most common cancers worldwide with a high mortality-to-incidence ratio. Accumulated evidence suggests that long noncoding RNAs (lncRNAs) are involved in gastric carcinogenesis. These transcripts are longer than 200 nucleotides and modulate gene expression at multiple molecular levels, inducing or inhibiting biological processes and diseases. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is one of the best-studied lncRNAs with comprehensive actions contributing to cancer progression. This lncRNA regulates gene expression at the transcriptional and posttranscriptional levels through interactions with microRNAs and proteins. In the present review, we discussed the molecular mechanism of MALAT1 and summarized the current knowledge of its expression in GC. Moreover, we highlighted the potential use of MALAT1 as a biomarker, including liquid biopsy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514724 | PMC |
| http://dx.doi.org/10.4251/wjgo.v15.i9.1520 | DOI Listing |
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