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| http://dx.doi.org/10.11604/pamj.2023.45.114.38344 | DOI Listing |
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Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis.
Crit Care Explor
February 2025
Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA.
Context: COVID-19 has been associated with features of a cytokine storm syndrome with some patients sharing features with the hyperinflammatory disorder, secondary hemophagocytic lymphohistiocytosis (sHLH).
Hypothesis: We hypothesized that proteins associated with sHLH from other causes will be associated with COVID-sHLH and that subjects with fatal COVID-sHLH would have defects in immune-related pathways.
Methods And Models: We identified two cohorts of adult patients presenting with COVID-19 at two tertiary care hospitals in Seattle, Washington in 2020 and 2021.
Qualitative Exploration and Proof of Concept Toward the Development of the Burnout Assessment for Developmental Disability Settings (BADDS) for Behavioral Health Providers.
J Autism Dev Disord
January 2025
Emory University School of Medicine, Atlanta, GA, USA.
The present evaluation aimed to begin development of a survey tool for measuring workplace stressors specific to behavioral health providers in clinical settings for autism and related developmental disabilities: the Burnout Assessment for Developmental Disability Settings (BADDS). BADDS development was guided by Patient-Reported Outcomes Measurement Information System (PROMIS; Cella et al., (Journal of Clinical Epidemiology, 63(11), 1179-1194, 2010) procedures.
View Article and Find Full Text PDFTherapeutical potential of natural products in treatment of pancreatic cancer: a review.
Mol Biol Rep
January 2025
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Pancreatic cancer remains as global health challenge, ranking as the seventh leading cause of cancer-related deaths worldwide with high mortality rates and a low five-year survival rate. Despite advancements in conventional therapies, including surgery, chemotherapy, and radiation, the overall survival rates for pancreatic cancer patients have shown minimal improvement. Consequently, there is an urgent need for alternative therapeutic strategies.
View Article and Find Full Text PDFMobile Applications for Longitudinal Data Collection: Web-based Survey Study of Former Intensive Care Patients.
J Med Syst
January 2025
Department of Intensive Care Medicine, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Purpose: Mobile health plays an important role in providing individualized information about the health status of patients. Limited information exists on intensive care unit (ICU) patients with the risk of suffering from the post-intensive care syndrome (PICS), summarizing long-term physical, mental and cognitive impairment. This web-based survey study aims to identify specific needs of former ICU patients for utilizing a newly developed, so called Post-Intensive Care Outcome Surveillance (PICOS) app to collect relevant PICS-related parameters.
View Article and Find Full Text PDFImpact of Delayed Surgery on Local Colorectal Neuroendocrine Tumors: Is Surveillance a Feasible Option?
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January 2025
Department of Surgery, Weill Cornell Medicine, New York, NY, USA.
Background: Guidelines for some pancreatic neuroendocrine tumors (NETs) have shifted towards active surveillance given the indolent nature of this malignancy. We sought to assess the safety of delayed surgery on colorectal NETs as a surrogate for surveillance.
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