AI Article Synopsis
- Alzheimer's disease can mess with sleep and cause a buildup of a harmful substance in the brain called amyloid beta.
- The study measured sleep patterns using a special device and compared them with brain scans to see if they could help identify early signs of amyloid buildup.
- It found that people with more sleep interruptions had more amyloid in certain parts of their brains, suggesting that sleep issues could help detect early Alzheimer's.
Article Abstract
Introduction: Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy-detected sleep parameters might be biomarkers for early amyloid burden.
Methods: Participants underwent a week of actigraphy and an amyloid positron emission tomography (PET) scan. Sleep duration and continuity disruption (sleep fragmentation and nocturnal awakenings) were extracted and compared between amyloid-positive and amyloid-negative participants. Then multiple linear regressions were used between mean or night-to-night intra-individual variability (standard deviation) of sleep parameters and brain amyloid burden in a voxel-wise analysis.
Results: Eighty-six subjects were included (80.3 ± 5.4 years; 48.8% of women). Amyloid-positive participants had a higher variability of sleep fragmentation compared to amyloid-negative participants. This parameter was associated with a higher amyloid burden in the frontal and parietal regions, and in the precuneus, in the whole sample.
Discussion: This study highlights the relevance of using variability in sleep continuity as a potential biomarker of early amyloid pathogenesis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512442 | PMC |
| http://dx.doi.org/10.1002/dad2.12460 | DOI Listing |
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