AI Article Synopsis
- The circadian system helps control sleep, hormones, and how we feel and react to rewards.
- When this system is messed up, like from jet lag, it can lead to problems with mood and health.
- In a study with mice, those with disrupted sleep schedules showed less motivation for food and more signs of anxiety and depression compared to those with normal sleep cycles.
Article Abstract
The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models. C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected. Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior. Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511878 | PMC |
| http://dx.doi.org/10.3389/fphys.2023.1225134 | DOI Listing |
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