A method for evaluation of α-glucosidase inhibition using .

MethodsX

Aesthetic Sciences and Health Program, Faculty of Thai Traditional and Alternative Medicine, Ubon Ratchathani Rajabhat University, Ubonratchathani 34000 Thailand.

Published: December 2023

The development of α-glucosidase inhibitors is essential for the prevention of type II diabetes. Previous research has investigated inhibition using isolated α-glucosidase, which may not accurately reflect physical processes. The method presented in this study aims to establish a rapid and inexpensive in vivo method to study the inhibition of α-glucosidase activity using as a model organism. This method can be used to calculate the IC value of compounds of interest for inhibition of α-glucosidase activity. The method established in this study can be used for screening of anti-diabetic compounds. •A rapid and inexpensive method to study the inhibition of α-glucosidase activity.•This method can be used to calculate the IC value of compounds of interest for inhibition of α-glucosidase activity.•This is a useful method for in vivo screening of anti-diabetic compounds.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511798PMC
http://dx.doi.org/10.1016/j.mex.2023.102373DOI Listing

Publication Analysis

Top Keywords

inhibition α-glucosidase
16
method
8
rapid inexpensive
8
method study
8
study inhibition
8
α-glucosidase activity
8
method calculate
8
calculate compounds
8
compounds interest
8
interest inhibition
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!