AI Article Synopsis
- This study compares two needle types used in endoscopic ultrasound-assisted tissue acquisition (EUS-TA) for collecting cancer tissue samples: the EZ Shot 3 Plus (EZ3) and the SonoTip TopGain (TopGain).
- Researchers analyzed data from EUS-TA cases between 2010 and 2021, finding that the TopGain needle collected tissue with a surface area of 4 mm or more in a higher percentage of cases (68.6%) compared to the EZ3 needle (42.9%).
- The findings suggest that using the TopGain needle is more effective for obtaining larger tissue samples necessary for accurate cancer gene panel testing, indicating its potential benefits in clinical practice.
Article Abstract
Background And Aim: Reports have indicated that a surface area of 4 mm or more of collected tissue sections could provide the recommended total DNA for the OncoGuide NCC Oncopanel system, which is a cancer gene panel test developed in Japan. We wished to compare the percentage of tissue sections collected by endoscopic ultrasound-assisted tissue acquisition (EUS-TA) with surface areas of ≥4 mm between a conventional needle, namely the EZ Shot 3 Plus (Olympus Medical Japan, Tokyo, Japan) (EZ3), and the recent SonoTip TopGain (MediGlobe, Rohrdorf, Germany) (TopGain).
Method: From April 2010 to December 2021, among 693 EUS-TA cases, EZ3 was used in 390 cases and TopGain in 45. The EZ3 and TopGain groups were matched in a 1:1 ratio with a tolerance of 0.2, with 35 patients each matched using propensity score analysis.
Results: The TopGain group had a significantly higher percentage of cases with a tissue area of ≥4 mm than the EZ3 group (42.9% 68.6%, = 0.030). Multivariate analysis revealed an association between TopGain and tissue areas of ≥4 mm (odds ratio 2.996, 95% confidence interval 1.068-8.403, = 0.037).
Conclusions: EUS-TA using TopGain significantly collected more ≥4 mm tissue area compared with EZ3, suggesting its usefulness for cancer gene panel testing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517436 | PMC |
| http://dx.doi.org/10.1002/jgh3.12965 | DOI Listing |
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