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Introduction: Infectious Bursal Disease Virus (IBDV) causes immunosuppression in chickens. While B-cell destruction is the main cause of humoral immunosuppression, bursal T cells from IBDV-infected birds have been reported to inhibit the mitogenic response of splenocytes, indicating that some T cell subsets in the infected bursa have immunomodulatory activities. CD4CD25TGFβ cells have been recently described in chickens that have immunoregulatory properties and play a role in the pathogenesis of Marek's Disease Virus.
Methods: To evaluate if CD4CD25TGFβ cells infiltrated the bursa of Fabricius (BF) following IBDV infection, and influenced the outcome of infection, birds were inoculated at either 2 days or 2 weeks of age with vaccine strain (228E), classic field strain (F52/70), or PBS (mock), and bursal cell populations were quantified by flow cytometry.
Results: Both 228E and F52/70 led to atrophy of the BF, a significant reduction of Bu1-B cells, and a significant increase in CD4 and CD8α T cells in the BF, but only F52/70 caused suppression of immune responses to a test antigen in younger birds, and clinical signs in older birds. Virus was cleared from the BF more rapidly in younger birds than older birds. An infiltration of CD4CD25T cells into the BF, and elevated expression of bursal TGFβ-1 mRNA was observed at all time points following infection, irrespective of the strain or age of the birds, but CD4TGFβcells and CD4CD25TGFβ cells only appeared in the BF at 28 dpi in younger birds. In older birds, CD4TGFβ cells and CD4CD25TGFβ cells were present at earlier time points, from 7dpi following 228E infection, and from 14 and 28 dpi following F52/70 infection, respectively.
Discussion: Our data suggest that an earlier infiltration of CD4TGFβ cells into the BF correlated with a delayed clearance of virus. However, the influx of CD4TGFβ cells and CD4CD25TGFβ into the BF did not correlate with increased pathogenicity, or immunosuppression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515216 | PMC |
| http://dx.doi.org/10.3389/fimmu.2023.1197746 | DOI Listing |
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