Background: Reducing venous drainage of the coronary sinus is a promising intervention for refractory angina. Coronary Sinus Reducer (CSR) System™ effectively treats patients with refractory angina, possibly by increasing coronary collateral circulation, and leads to an improvement in their symptoms and quality of life. In patients with impaired left ventricular function and electrocardiographic dyssynchrony, cardiac resynchronization therapy (CRT) is an established treatment. However, there is only one published case report of CRT in a patient implanted with a CSR system. We present the first case series of CRT in patients implanted with the CSR system.
Case Summary: This case series describes three patients. The first case demonstrated that CRT is feasible in patients implanted with a CSR system. The second case is the first report of a left ventricular lead extraction after CSR, and the third case was complicated due to the patient's medical history; however, CSR system implantation was feasible without major complications.
Discussion: Our results suggest that CRT is feasible in patients implanted with a CSR system, and lead extraction after CSR system implantation is possible. However, lead extraction in cases of severe adhesions around the CSR system and the coronary sinus may be associated with a high risk of complications; alternative options should be discussed at an early stage.
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http://dx.doi.org/10.1093/ehjcr/ytad455 | DOI Listing |
BMC Bioinformatics
January 2025
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
In cell line perturbation experiments, a collection of cells is perturbed with external agents and responses such as protein expression measured. Due to cost constraints, only a small fraction of all possible perturbations can be tested in vitro. This has led to the development of computational models that can predict cellular responses to perturbations in silico.
View Article and Find Full Text PDFAltern Lab Anim
January 2025
Roper Toxicology Consulting Limited, Edinburgh, UK.
Increasing the use of microphysiological systems (MPS) in Three Rs and regulatory applications is a nuanced but important goal, which would also help increase their scientific impact. There are three distinct and important stakeholder groups that each play a unique role in expediting the use of MPS for regulatory purpose - namely, commercial MPS developers, end-users and regulators. Additionally, non-profit organisations, such as the 3Rs Collaborative (3RsC), can help coordinate these efforts.
View Article and Find Full Text PDFJ Health Organ Manag
January 2025
University of Malta, Msida, Malta.
Purpose: This study explores how corporate social responsibility (CSR) and artificial intelligence (AI) can be combined in the healthcare industry during the post-COVID-19 recovery phase. The aim is to showcase how this fusion can help tackle healthcare inequalities, enhance accessibility and support long-term sustainability.
Design/methodology/approach: Adopting a viewpoint approach, the study leverages existing literature and case studies to analyze the intersection of CSR and AI.
PLoS One
January 2025
Faculty of Humanities and Social Sciences, Macao Polytechnic University, Macao, China.
Corporate social responsibility (CSR) has been widely discussed. However, the existing literature does not delve into the theoretical mechanism to show how companies adjust their CSR in the face of minimum wage increases. This may be due to the lack of a theoretical framework that clarifies the relationship between minimum wage increases and CSR adjustments.
View Article and Find Full Text PDFChem Soc Rev
January 2025
School of materials science and engineering, Smart sensing interdisciplinary science center, Nankai university, Tianjin 300350, P. R. China.
The inspirations from nature always enlighten us to develop advanced science and technology. To survive in complicated and harsh environments, plants and animals have evolved remarkable capabilities to control fluid transfer sophisticated designs such as wettability contrast, oriented micro-/nano-structures, and geometry gradients. Based on the bioinspired structures, the on-surface fluid manipulation exhibits spontaneous, continuous, smart, and integrated performances, which can promote the applications in the fields of heat transfer, microfluidics, heterogeneous catalysis, water harvesting, Although fluid manipulating interfaces (FMIs) have provided plenty of ideas to optimize the current systems, a comprehensive review of history, classification, fabrication, and integration focusing on their interfacial chemistry and asymmetric structure is highly required.
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