AI Article Synopsis
- Electrical stimulation has been extensively studied for its potential to enhance wound healing, showing benefits like antibacterial effects, growth factor secretion, and improved blood vessel formation.
- Despite its promising results, electrical stimulation has not yet been widely accepted as an established treatment method due to inconsistencies in reporting and application.
- The article proposes a standardized protocol for in vitro studies to ensure replicable results, aiming to unify different approaches and facilitate the transition from laboratory research to clinical practice for effective wound healing treatments.
Article Abstract
Electrical stimulation as a mode of external enhancement factor in wound healing has been explored widely. It has proven to have multidimensional effects in wound healing including antibacterial, galvanotaxis, growth factor secretion, proliferation, transdifferentiation, angiogenesis, etc. Despite such vast exploration, this modality has not yet been established as an accepted method for treatment. This article reviews and analyzes the approaches of using electrical stimulation to modulate wound healing and discusses the incoherence in approaches towards reporting the effect of stimulation on the healing process. The analysis starts by discussing various processes adapted in in vitro, in vivo, and clinical practices. Later it is focused on in vitro approaches directed to various stages of wound healing. Based on the analysis, a protocol is put forward for reporting in vitro works in such a way that the outcomes of the experiment are replicable and scalable in other setups. This work proposes a ground of unification for all the in vitro approaches in a more sensible manner, which can be further explored for translating in vitro approaches to complex tissue stimulation to establish electrical stimulation as a controlled clinical method for modulating wound healing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808217 | PMC |
| http://dx.doi.org/10.1007/s10439-023-03371-2 | DOI Listing |
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