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[Safety evaluation of tetravalent meningococcal conjugate vaccine in combination with the inactivated poliomyelitis vaccine and diphtheria-tetanus-acellular pertussis vaccine for infants].
Zhonghua Yu Fang Yi Xue Za Zhi
January 2025
Immunization Program Institute of Shaanxi Provincial Center for Disease Control and Prevention, Xi'an 710054, China.
To investigate the safety of the tetravalent meningococcal conjugate vaccine (MPCV-ACYW) in combination with the inactivated poliomyelitis (IPV) vaccine and diphtheria-tetanus-acellular pertussis (DTaP) vaccine for infants aged 3-5 months and provide real-world evidence for the immunization strategy of vaccine combination. From June to October 2023, a total of 600 3-month-old infants were selected and divided into three groups: control group, mono-vaccination group and combined vaccination group. They were simultaneously or individually vaccinated with MPCV-ACYW, IPV and DTaP vaccines at 3, 4, and 5 months of age, respectively.
View Article and Find Full Text PDFPeriodontal pathogens and obesity in the context of cardiovascular risks across age groups.
Front Oral Health
January 2025
Department of Cardiovascular Pathology and Diet Therapy, Federal Research Centre for Nutrition, Biotechnology and Food Safety, Moscow, Russia.
Background: Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity among noncommunicable diseases. Over the past decade, there has been a notable increase in the prevalence of CVDs among young individuals. Obesity, a well-known risk factor for CVDs, is also associated with various comorbidities that may contribute to cardiovascular risk.
View Article and Find Full Text PDFAssessment of biofilm formation, antibiotic resistance patterns, and the prevalence of adhesion-related genes in clinical isolates.
Heliyon
January 2025
Department of Basic Medical Sciences, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran.
Background: This study aimed to evaluate the biofilm formation abilities of clinical strains, assess their antibiotic susceptibility patterns, and identify the prevalence of adhesion-associated genes.
Methodology: In this study, a total of 60 strains were collected from urine, pus, wounds, blood, body fluid, and sputum in health centers affiliated with Abadan University of Medical Sciences, Iran. Strains were identified via microbiological methods and polymerase chain reaction (PCR) to target the gene.
Remote assessment of physical fitness via videoconferencing: a systematic review.
BMC Sports Sci Med Rehabil
January 2025
Institute of Movement and Sport, Karlsruhe University of Education, Bismarckstraße 10, 76133, Karlsruhe, Germany.
Physical fitness is a critical marker of overall health across all age groups, influencing longevity and quality of life. This systematic review assessed the use of remote physical fitness assessments, a crucial adaptation during the COVID-19 pandemic that broadened access to health monitoring outside traditional settings. The review included 35 studies, covering various age groups and health conditions, and evaluated 48 physical fitness tests across eight physical fitness components.
View Article and Find Full Text PDFLipid-Rapamycin Nanovaccines Overcome the Antidrug Antibody Barrier in Biologic Therapies.
ACS Nano
January 2025
Wuya Faculty of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Antidrug antibodies (ADAs) against biologics present a major challenge for sustained biotherapy, including enzyme replacement therapies and adeno-associated virus (AAV) gene therapies. These antibodies arise from undesirable immune responses, leading to altered pharmacokinetics, reduced efficacy, and adverse reactions. In this study, we introduced a rationally designed lipid-rapamycin (Rapa)-based nanovaccine to restore immune tolerance to biologics and overcome drug resistance.
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