AI Article Synopsis
- IVIG has been used for over 40 years for various medical purposes, including kidney transplantation, treating antibody-mediated rejection, and preventing certain infectious diseases.
- It works through complex and diverse mechanisms that may combine to enhance its effectiveness, but can also lead to serious adverse effects.
- This review aims to summarize the mechanisms of action, clinical uses, potential risks, and preventative strategies for IVIG and hyperimmune globulin treatments.
Article Abstract
Intravenous immunoglobulin (IVIG) has been developed for over 40 years. The mechanisms of action of IVIG are complex and diverse, and there may be multiple mechanisms that combine to influence it. IVIG has been used in kidney transplantation for desensitization, treatment of antibody-mediated rejection, and ABO-incompatible transplantation. and treatment or prevention of some infectious diseases. Hyperimmune globulins such as cytomegalovirus hyperimmune globulin (CMV-IG) and hepatitis B hyperimmune globulin (HBIG) have also been used to protect against cytomegalovirus and hepatitis B virus, respectively. However, IVIG is also associated with some rare but serious adverse effects and some application risks, and clinicians need to weigh the pros and cons and develop individualized treatment programs to benefit more patients. This review will provide an overview of the multiple mechanisms of action, clinical applications, adverse effects, and prophylactic measures of IVIG, and hyperimmune globulin will also be introduced in it.
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| http://dx.doi.org/10.1016/j.clim.2023.109782 | DOI Listing |
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