AI Article Synopsis
- Extracellular vesicles (EVs) are crucial for communication between cells and are linked to how cancer develops, particularly in low-oxygen (hypoxic) environments.
- Hypoxic EVs have unique proteins and other molecules that can change the behavior of recipient cells, and enhancing these EVs could improve their effectiveness in therapies.
- This review will cover how hypoxia affects EVs, their role in cancer progression, and the challenges and advancements in using hypoxic EVs for cancer treatment.
Article Abstract
Extracellular vesicles (EVs) play a pivotal role in intercellular communication and have been implicated in cancer progression. Hypoxia, a pervasive hallmark of cancer, is known to regulate EV biogenesis and function. Hypoxic EVs contain a specific set of proteins, nucleic acids, lipids, and metabolites, capable of reprogramming the biology and fate of recipient cells. Enhancing the intrinsic therapeutic efficacy of EVs can be achieved by strategically modifying their structure and contents. Moreover, the use of EVs as drug delivery vehicles holds great promise for cancer treatment. However, various hurdles must be overcome to enable their clinical application as cancer therapeutics. In this review, we aim to discuss the current knowledge on the hypoxic regulation of EVs. Additionally, we will describe the underlying mechanisms by which EVs contribute to cancer progression in hypoxia and outline the progress and limitations of hypoxia-related EV therapeutics for cancer.
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| http://dx.doi.org/10.1016/j.jconrel.2023.09.034 | DOI Listing |
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