Seventy strains of B. asteroides isolated from the honey bees Apis mellifera and A. cerana raised in 15 different countries, 73 strains of B. indicum from Apis dorsata and A. cerana from The Philippines and 28 strains of B. globosum isolated from feces of various animals and sewage, were studied for the existence of related structures among their plasmid complements with the Southern blot-hybridization technique. Thirteen different structures were found in B. asteroides and three in B. indicum and B. globosum. A total of twenty five strains were used as source of probes in the hybridization experiments.
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Alzheimers Dement
December 2024
Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Background: Astrocytes secrete neuromodulators, neurohormones, trophic factors, and synaptogenesis modulators. Trophic factors regulate various cellular processes including synaptic transmission. Astrocytes have critical roles in synaptic development and plasticity.
View Article and Find Full Text PDFInt Rev Immunol
January 2025
Department of Cardiology, Loudi Central Hospital, Loudi City, Hunan Province, China.
Objective: Heart failure (HF) causes structural and functional changes in the heart, with the pyroptosis-mediated inflammatory response as the core link in HF pathogenesis. E3 ubiquitin ligases participate in cardiovascular disease progression. Here, we explored the underlying molecular mechanisms of E3 ubiquitin ligase Smurf1 in governing HF.
View Article and Find Full Text PDFZhonghua Kou Qiang Yi Xue Za Zhi
January 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan430079, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, The First Affiliated Hospital of Soochow University, Collaborative Innovation Center of Hematology, Suzhou 215006, Jiangsu Province, China.
Objective: To study the molecular mechanism of functional defect of protein C (PC) caused by point mutations of human protein C gene ( ) N355S , G392E and T314A.
Methods: The wild-type and mutant plasmids (PC, PC, PC, PC) of gene were constructed and transiently transfected into HEK293 cells. The expression of mutant proteins in vitro were tested.
Ann Clin Transl Neurol
December 2024
Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, P. R. China.
Background: Variants in the GABRA2 gene, which encodes the α2 subunit of the γ-aminobutyric acid A receptor, have been linked to a rare form of developmental and epileptic encephalopathy (DEE) referred to as DEE78. Only eight patients have been reported globally. This study presents the clinical presentation and genetic analysis of a Chinese family with a child diagnosed with DEE78, due to a novel GABRA2 variant.
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