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http://dx.doi.org/10.1186/s12917-023-03734-w | DOI Listing |
Am J Sports Med
January 2025
Department of Pharmacology and Biostatistics, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Background: Patellar instability is frequently encountered by orthopaedic surgeons. One of the major risk factors of this condition is underlying trochlear dysplasia (TD). Recent trends have indicated the use of multiple procedures to correct patellar instability under these conditions.
View Article and Find Full Text PDFMol Pharm
January 2025
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, 8000 Utopia Parkway, Queens, New York 11439, United States.
Although glycine is the simplest of the amino acids, its solution and solid-state properties are far from straightforward. The aqueous solubility of glycine plays an important role in various applications, including nutrition, food products, biodegradable plastics, and drug development. There is evidence that glycine in subsaturated pH 3-8 solutions forms a dimer, as suggested by several techniques.
View Article and Find Full Text PDFAntonie Van Leeuwenhoek
January 2025
Department of Biological Sciences and Biotechnology, Hannam University, 1646,Yuseong-Daero, Yuseong-Gu, Daejeon, 34430, Republic of Korea.
Alzheimers Dement
December 2024
University of Kansas Medical Center, Kansas City, KS, USA.
Background: Understanding the proteomes of specific cell types within the brain is crucial for elucidating the mechanisms underlying Alzheimer's disease (AD). However, the isolation and analysis of these diverse and low-abundance cell populations remain significant challenges. This study aims to assess GeoMxTM Digital Spatial Profiler (DSP) by NanoString Technologies (NanoString, Seattle, USA) capable of spatially resolving protein expression profile of AD brains extracted from formalin-fixed paraffin-embedded (FFPE) specimens.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Exeter, Exeter, Devon, United Kingdom.
Background: Post-mortem neuropathological examinations following the first active immunotherapy strategy (AN-1792, Elan Pharmaceuticals, 2000) for Alzheimer's disease (AD) have evidenced amyloid-β (Aβ) plaque clearance and increased microglial phagocytic activity in immunised individuals. This study characterises the epigenetic profiles of individuals who underwent Aβ immunotherapy with the aim of discovering novel therapeutic targets and biomarkers.
Method: DNA and RNA was isolated from post-mortem prefrontal cortex tissue of immunised cases (n = 14) who received varying doses (ug) and number of doses during the trial period.
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