AI Article Synopsis
- Eleven new diterpenoids were found in a whole plant, categorized into five different carbon skeleton types, including one never seen before.
- * Spectroscopic methods, single-crystal X-ray diffraction, and electronic circular dichroism were used to determine their structures and configurations.
- * Two of these compounds showed activity against the Zika virus, effectively inhibiting its replication without harming host cells at higher concentrations.*
Article Abstract
Eleven diterpenoids, wulfenioidins D-N (-), classified into five distinct carbon skeletons with one unreported framework, and four modified abietane diterpenoids were isolated from the whole plant of . The structures and absolute configurations were characterized by spectroscopic methods, single-crystal X-ray diffraction, and electronic circular dichroism analyses. Compounds and exhibited activity against Zika virus (ZIKV) with EC values of 8.07 and 8.50 μM, respectively, and showed no significant cytotoxicity toward Vero cells at 100 μM. Western blot and immunofluorescence experiments showed that compounds and interfered with the replication of the ZIKV by inhibiting the expression of the ZIKV envelope (E) protein.
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| http://dx.doi.org/10.1021/acs.jnatprod.3c00543 | DOI Listing |
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