Despite a well-developed and growing body of work on the directed evolution of hemoproteins, the potential of hemoproteins to catalyze non-natural reactions remains underexplored. This paper reports a new biocatalytic strategy for the one-pot synthesis of unnatural α-amino acids. Engineered variants of dual-function hemoglobin were found to efficiently catalyze N-H insertion and C-H sp alkylation, providing moderate to excellent yields (57%-95%) of unnatural α-amino acid derivatives and turnover numbers (1425-2375).
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| http://dx.doi.org/10.1021/acs.orglett.3c02537 | DOI Listing |
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