AI Article Synopsis
- Targeted therapy using protein kinase inhibitors (PKIs) has significantly improved survival and quality of life for patients with non-small cell lung cancer (NSCLC).
- PKIs are often given in fixed doses, but there is a lot of variation in how patients metabolize these drugs, suggesting the need for tailored dosing.
- This review focuses on the pharmacokinetic traits of PKIs and the potential benefits of therapeutic drug monitoring (TDM) to personalize treatment for NSCLC patients, addressing the lack of evidence for PKI concentration-effect relationships in oncology.
Article Abstract
Targeted therapy with protein kinase inhibitors (PKIs) represents one of the important treatment options for non-small cell lung cancer (NSCLC). It has contributed to improve patients' survival and quality of life significantly. These anticancer drugs are administrated orally in flat-fixed doses despite the well-known large interpatient pharmacokinetic variability and the possible need for dose individualization. To optimize and individualize dosing of PKIs, and thereby increasing the effectiveness and safety of the treatment, therapeutic drug monitoring (TDM) is the most frequently mentioned method. Unlike other areas of medicine, TDM has been rather exceptional in oncological practise since there is a little evidence or no data for concentration-effect relationships of PKIs. Therefore, the aim of this review is to summarize the pharmacokinetic characteristics of PKIs and provide the evidence supporting the use of TDM for personalised treatment of patients with NSCLC.
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| http://dx.doi.org/10.14712/23362936.2023.16 | DOI Listing |
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