AI Article Synopsis
- The text discusses recent advancements in using Selectfluor for C-H bond functionalization of N-heteroarenes, which is a more sustainable alternative to traditional methods involving toxic metals or peroxides.
- Selectfluor allows for diverse chemical modifications, making it a valuable tool in organic synthesis.
- The review organizes the strategies into four categories: carbon-carbon, carbon-nitrogen, carbon-chalcogen, and carbon-halogen bond formations, and also explores the mechanisms and conditions for these reactions.
Article Abstract
Herein, recent developments for Selectfluor-mediated C-H functionalization of N-heteroarenes are described. This type of C-H bond activation is an attractive and competitive alternative to traditional methodologies, allowing the functionalization of a variety of chemical functions. In addition, Selectfluor is a more sustainable and economically accessible oxidant compared with expensive/toxic metals or hazardous peroxides. For a practical understanding, the current review classified systematically the reported strategies in four subsections as follows: (1) carbon-carbon formation, (2) carbon-nitrogen bond formation, (3) carbon-chalcogen bond, and (4) carbon-halogen bond formation. Mechanistic aspects and reaction conditions are fully discussed to provide an understanding of the aspects that govern C-H functionalization in N-heteroarenes mediated by Selectfluor.
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| http://dx.doi.org/10.1007/s41061-023-00437-6 | DOI Listing |
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