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Human Milk-Derived Fortifier to Reduce Hospital-Acquired Malnutrition in Uncomplicated Gastroschisis: A Case Report.
AJP Rep
July 2024
Neonatal Intensive Care Unit, Texas Health Harris Methodist Hospital Fort Worth, Fort Worth, Texas.
Gastroschisis is one of the most common congenital gastrointestinal disorders, occurring in about one in 1,953 infants born each year in the United States. Infants with gastroschisis rely on total parenteral nutrition (TPN) preoperatively, and due to intestinal function and dysmotility issues, continue to face feeding challenges postclosure, including feeding intolerance and increased risk of necrotizing enterocolitis (NEC). Postclosure, human milk-feeding is preferred over infant formula because of its associated reduced risk of feeding intolerance and NEC.
View Article and Find Full Text PDFChallenges and lessons from the COVID-19 pandemic for Health Surveillance in Brazil: reflections on technologies, models, and system organization.
Rev Bras Epidemiol
December 2024
Fundação Oswaldo Cruz, Center for Epidemiology and Health Surveillance - Brasília (DF), Brazil.
The term "health surveillance" encompasses a wide range of activities, including the monitoring and observation of harms and diseases. We will investigate the most well-known aspect of health surveillance, namely the monitoring of communicable diseases. To illustrate our discussion, we will use the pandemic caused by the SARS-CoV-2 virus as a case study.
View Article and Find Full Text PDFMolecular Investigation of SNAC as an Oral Peptide Permeation Enhancer in Lipid Membranes via Solid-State NMR.
Mol Pharm
December 2024
Pharmaceutical Sciences and Clinical Supply, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
Oral peptide therapeutics are increasingly favored in the pharmaceutical industry for their ease of use and better patient adherence. However, they face challenges with poor oral bioavailability due to their high molecular weight and surface polarity. Permeation enhancers (PEs) like salcaprozate sodium (SNAC) have shown promise in clinical trials, achieving about 1% bioavailability.
View Article and Find Full Text PDFA Remotely Delivered Light-Intensity Physical Activity Intervention for Older Cancer Survivors: Protocol for a Feasibility Randomized Controlled Trial.
JMIR Res Protoc
December 2024
Department of Pediatrics, University of New Mexico, Albuquerque, NM, United States.
Background: Older cancer survivors face age- and treatment-related comorbidities, including physical functional impairment, which are exacerbated by physical inactivity and sedentary behavior. Regular physical activity can reduce this risk, yet less than 30% of older cancer survivors meet the recommended guidelines for physical activity.
Objective: This study aims to describe the design, methods, and rationale for a remotely delivered intervention that uses a whole-of-day approach to physical activity in older cancer survivors.
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