Ten previously undescribed meroterpenoids, cyclohexenoneterpenes A-J (1-7, 18-20), together with 10 known analogues (8-17) were isolated from the mangrove-associated fungus Penicillium sp. N-5. Their structures were elucidated on the basis of extensive spectroscopic and mass spectrometric data. The absolute configurations of the undescribed compounds were assigned by electronic circular dichroism calculations, the modified Mosher's method, NMR calculations and DP4+ analysis. In the bioassay, compounds 10, 11, 15, and 20 exhibited cytotoxicities against SNB-19, MDA-MB-231, MDA-MB-435 and HCT-116 cell lines with IC values ranging from 1.4 to 19.1 μM.
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http://dx.doi.org/10.1016/j.phytochem.2023.113868 | DOI Listing |
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