AI Article Synopsis

  • - Oxidative stress (OS) occurs when there's too much reactive oxygen species (ROS) and not enough antioxidant defenses, leading to cell damage and contributing to various diseases, particularly those related to high blood sugar levels, like diabetic retinopathy (DR).
  • - Diabetic retinopathy, a complication of diabetes, is a major cause of vision loss and is linked to OS, which interferes with important metabolic pathways and results in damaging substances like advanced glycation end products (AGEs).
  • - Understanding how OS contributes to DR is essential, as it drives harmful changes in retinal cells, leading to inflammation and cell death, which can severely affect eyesight in individuals with diabetes.

Article Abstract

Oxidative stress (OS) is a cytopathic outcome of excessively generated reactive oxygen species (ROS), down regulated antioxidant defense signaling pathways, and the imbalance between the produced radicals and their clearance. It plays a role in the genesis of several illnesses, especially hyperglycemia and its effects. Diabetic retinal illness, a micro vascular side effect of the condition, is the prime reason of diabetic related blindness. The OS (directly or indirectly) is associated with diabetic retinopathy (DR) and related consequences. The OS is responsible to induce and interfere the metabolic signaling pathways to enhance influx of the polyol cascades and hexosamine pathways, stimulate Protein Kinase-C (PKC) variants, and accumulate advanced glycation end products (AGEs). Additionally, the inequity between the scavenging and generation of ROS is caused by the epigenetic alteration caused by hyperglycemia that suppresses the antioxidant defense system. Induced by an excessive buildup of ROS, retinal changes in structure and function include mitochondrial damage, cellular death, inflammation, and lipid peroxidation. Therefore, it is crucial to comprehend and clarify the mechanisms connected to oxidative stress that underlie the development of DR.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2023.109650DOI Listing

Publication Analysis

Top Keywords

oxidative stress
12
diabetic retinopathy
8
antioxidant defense
8
signaling pathways
8
correlation oxidative
4
diabetic
4
stress diabetic
4
retinopathy updated
4
updated review
4
review oxidative
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!