Key Clinical Message: Colorectal carcinoma (CRC) should be suspected in pediatric patients with a bowel obstruction in an emergency setting. Evidence-based surgical management with chemotherapy is crucial to prevent adverse outcomes.
Abstract: CRC should be suspected in pediatric patients presenting to the emergency with unspecified abdominal pain. An erect X-ray abdomen and a colonoscopy should be initial diagnostic tests. If colonoscopy raises suspicion of CRC, a biopsy during colonoscopy is indicated. A computed tomography scan of the chest, abdomen, and pelvis will also aid in diagnosis, staging, and planning intervention. In advanced cases, the intervention includes proximal diversion, bypass, and bowel resection with anastomosis. Sometimes postoperative chemotherapy may be required.
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http://dx.doi.org/10.1002/ccr3.7930 | DOI Listing |
Aliment Pharmacol Ther
January 2025
Gastrointestinal and Liver Theme, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and the University of Nottingham, School of Medicine, Queen's Medical Centre, Nottingham, UK.
Background: Colorectal cancer (CRC) is the third most common cancer in the United Kingdom and the second largest cause of cancer death.
Aim: To develop and validate a model using available information at the time of faecal immunochemical testing (FIT) in primary care to improve selection of symptomatic patients for CRC investigations.
Methods: We included all adults (≥ 18 years) referred to Nottingham University Hospitals NHS Trust between 2018 and 2022 with symptoms of suspected CRC who had a FIT.
Cureus
December 2024
General Surgery, Aneurin Bevan University Health Board, Newport, GBR.
Aim: To assess recent colonoscopies and CT scans in conjunction with the feacal immunochemical test (FIT) for possibly downgrading urgent suspected cancer (USC) referrals.
Methods: A retrospective single-centre study was conducted, including all USC referrals for colonoscopy in 2022, excluding anal cancers. The CT and colonoscopy findings for a two-year period prior to the referral, along with the FIT result (if done), were noted.
Eur J Emerg Med
December 2024
Sorbonne Université, IMProving Emergency Care (IMPEC) FHU Paris.
Curr Diab Rep
December 2024
Department of Surgery, Division of Colon and Rectal Surgery, University of California, 333 The City Blvd West, Suite 1600, Suite 1600, Irvine, CA, USA, 92868-3298.
Purpose Of Review: This article aims to review the recent literature assessing the relationship between obesity and colorectal carcinogenesis, the effect of obesity on the treatment of colorectal cancer (CRC), tools available to help augment the increased risk, and outcomes for patients who are affected by both obesity and colorectal cancer.
Recent Findings: The biochemical mechanisms contributing to CRC carcinogenesis are not well understood but are suspected to be related to adipose tissue leading to a pro-inflammatory state and changes in the gut microbiome. Individuals with obesity are at higher risk for CRC development, worse oncologic outcomes, and increased rates of post-operative complications.
J Gastroenterol Hepatol
November 2024
Hereditary Cancer Clinic, Cancer Prevention Center, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea.
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