Objectives: This study assessed whether there was a time-of-day effect on nausea reports in participants during studies employing circadian protocols.
Methods: Visual-analog-scales of nausea ratings were recorded from 34 participants (18-70years; 18 women) during forced desynchrony studies, where meals were scheduled at different circadian phases. Subjective nausea reports from a further 81 participants (18-35years; 36 women) were recorded during constant routine studies, where they ate identical isocaloric hourly snacks for 36-40 hours.
Results: Feelings of nausea varied by circadian phase in the forced desynchrony studies, peaking during the biological night. Nausea during the constant routine was reported by 27% of participants, commencing 2.9 ± 5.2 hours after the midpoint of usual sleep timing, but was never reported to start in the evening (4-9 PM).
Conclusions: Nausea occurred more often during the biological night and early morning hours. This timing is relevant to overnight and early morning shift workers and suggests that a strategy to counteract that is to pay careful attention to meal timing.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10947563 | PMC |
http://dx.doi.org/10.1016/j.sleh.2023.08.004 | DOI Listing |
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