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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513066 | PMC |
| http://dx.doi.org/10.1523/JNEUROSCI.0881-23.2023 | DOI Listing |
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Technology in the Trenches: The Impact of evolving technologies on Combat Mental Health.
Curr Psychiatry Rep
February 2025
Center for Military Medicine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Purpose Of Review: Medicine and specifically mental health have been affected by emerging technologies advancing mental health treatment while at the same time bringing new challenges and stressors to the battlefield, military systems, and the warfighter.
Recent Findings: This article reviews the evolving positive and negative impacts of technology on combat mental health and treatment. A history of technology and military mental health concerns and services is followed by an overview of present benefits and risks.
Genome-Scale Community Model-Guided Development of Bacterial Coculture for Lignocellulose Bioconversion.
Biotechnol Bioeng
January 2025
School of Energy Science and Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.
Microbial communities have shown promising potential in degrading complex biopolymers, producing value-added products through collaborative metabolic functionality. Hence, developing synthetic microbial consortia has become a predominant technique for various biotechnological applications. However, diverse microbial entities in a consortium can engage in distinct biochemical interactions that pose challenges in developing mutualistic communities.
View Article and Find Full Text PDFQuantitative profiling of human translation initiation reveals elements that potently regulate endogenous and therapeutically modified mRNAs.
Mol Cell
January 2025
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA. Electronic address:
mRNA therapeutics offer a potentially universal strategy for the efficient development and delivery of therapeutic proteins. Current mRNA vaccines include chemically modified nucleotides to reduce cellular immunogenicity. Here, we develop an efficient, high-throughput method to measure human translation initiation on therapeutically modified as well as endogenous RNAs.
View Article and Find Full Text PDFEmbedding a culture of research in Canadian community hospitals: a qualitative study.
Health Res Policy Syst
December 2024
Niagara Health Knowledge Institute, Niagara Health, St. Catharines, ON, Canada.
Background: In Canada, academic hospitals are the principal drivers of research and medical education, while community hospitals provide patient care to a majority of the population. Benefits of increasing community hospital research include improved patient outcomes and access to research, enhanced staff satisfaction and retention and increased research efficiency and generalizability. While the resources required to build Canadian community hospital research capacity have been identified, strategies for strengthening organizational research culture in these settings are not well defined.
View Article and Find Full Text PDFModulating the Potency of BRD4 PROTACs at the Systems Level with Amine-Acid Coupling Reactions.
J Med Chem
January 2025
Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48104, United States.
Protein degradation using proteolysis targeting chimeras (PROTACs) represents a promising therapeutic strategy. PROTACs are heterobifunctional molecules that consist of a target-binding moiety and an E3 ligase binding moiety, connected by a linker. These fragments are frequently united via amide bonds.
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