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Potential therapeutic value of dietary polysaccharides in cardiovascular disease: Extraction, mechanisms, applications, and challenges.
Int J Biol Macromol
January 2025
Department of Cardiology, Wenzhou Central Hospital, Wenzhou 325000, China. Electronic address:
Dietary polysaccharides, recognised as significant natural bioactive compounds, have demonstrated promising potential for the prevention and treatment of cardiovascular disease (CVD). This review provides an overview of the biological properties and classification of polysaccharides, with particular emphasis on their extraction and purification methods. The paper then explores the diverse mechanisms by which polysaccharides exert their effects in CVD, including their antioxidant activity, protection against ischemia-reperfusion injury, anti-apoptotic properties, protection against diabetic cardiomyopathy, anticoagulant and antithrombotic effects, prevention of ventricular remodeling, and protection against vascular injury.
View Article and Find Full Text PDFResults of a multinational survey on the diagnostic and management practices of catheter-related arterial thrombosis in children and neonates: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis.
J Thromb Haemost
December 2024
Pediatric Hematology-Oncology Unit, Division of Pediatrics, Department Woman-Mother-Child, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland; Pediatric Hematology-Oncology Unit, Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Ente Ospedaliero Cantonale, Bellinzona, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland. Electronic address:
Background: Arterial thrombosis is increasingly recognized in children and is most commonly related to the presence of an arterial catheter. Diagnosis and treatment of arterial thrombosis in children varies widely and consists of commonly available anticoagulants and antiplatelet drugs. No evidence-based guidelines exist for management strategies for catheter-related arterial thrombosis (CAT).
View Article and Find Full Text PDFLong-term efficacy of subclavian vein stenting in a patient on hemodialysis complicated by stasis dermatitis due to subclavian vein stenosis.
J Cardiol Cases
December 2024
Department of Cardiology, Japanese Red Cross Ashikaga Hospital, Ashikaga, Japan.
Unlabelled: Data about the long-term safety and efficacy of stent implantation for central venous stenosis in patients on dialysis are limited. We report the case of a 66-year-old man on hemodialysis for end-stage renal disease who presented with stasis dermatitis around an arteriovenous shunt with ulceration of the left forearm. Computed tomography angiography showed a tight stenosis of the proximal left subclavian vein and the development of collateral blood vessels around the stenosis.
View Article and Find Full Text PDFMinor trauma and venous thromboembolism: the threshold for antithrombotic prophylaxis.
Haematologica
December 2024
Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario.
Trauma is an established risk factor for venous thromboembolism (VTE). Whether minor trauma is linked to greater risk of VTE remains unclear given that many studies evaluating trauma and VTE risk have not differentiated risk by trauma severity. Furthermore, the underlying risk of VTE is not uniform across all injured patients.
View Article and Find Full Text PDFManaging drug-drug interactions with mavacamten: A focus on combined use of antiarrhythmic drugs and anticoagulants.
Heart Rhythm
November 2024
Barts Heart Centre, Barts Health NHS Trust, London, UK; Center for Inherited Cardiovascular Diseases, WellSpan Health, Lancaster, Pennsylvania, USA; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA; Center for Inherited Cardiovascular Disease, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. Electronic address:
Article Synopsis
- * Its effectiveness can be influenced by the individual's CYP2C19 genetic profile and interactions with other medications that affect liver enzymes, which could lead to adverse effects or reduced effectiveness.
- * The paper aims to provide healthcare professionals with guidance on safely prescribing mavacamten alongside commonly used drugs for managing atrial fibrillation in HCM patients, emphasizing the importance of genetic factors and patient safety monitoring.
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