AI Article Synopsis
- Researchers explored the relationship between frailty and depression using Mendelian randomization to determine if one causes the other.
- They analyzed genetic data on frailty and depression from large databases like the UK Biobank and Psychiatric Genomics Consortium.
- The findings indicate a significant bidirectional association: frailty increases the risk of depression, and depression also contributes to the development of frailty, even when controlling for factors like body mass index and physical activity.
Article Abstract
Frailty and depression were linked in observational studies, but the causality remains ambiguous. We intended to explore it using Mendelian randomization (MR). We obtained frailty genome-wide association study (GWAS) data from UK Biobank and TwinGen meta-analysis, and depression GWAS data from Psychiatric Genomics Consortium (PGC) and FinnGen (respectively recorded as PD and FD). We performed univariable and multivariable-adjusted MR with adjustments for body mass index (BMI) and physical activity (PA). Frailty was significantly associated with elevated risks of PD (OR, 1.860; 95% CI, 1.439 to 2.405; < 0.001) and FD (OR, 1.745; 95% CI, 1.193 to 2.552; = 0.004), and depression was meanwhile a susceptible factor for frailty (PD: β, 0.146; 95% CI, 0.086 to 0.201; < 0.001; and FD: β, 0.112; 95% CI, 0.051 to 0.174; < 0.001). This association was robust after adjustments for BMI or PA. Our study provides evidence of the bidirectional causal association between frailty and depression from genetic perspectives.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511184 | PMC |
| http://dx.doi.org/10.1126/sciadv.adi3902 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cut-Off Points for Low Relative 30-s Sit-to-Stand Power and Their Associations With Adverse Health Conditions.
J Cachexia Sarcopenia Muscle
February 2025
Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Background: Despite muscle power derived from the 5-rep sit-to-stand (STS) test having been demonstrated to be a valuable biomarker in older individuals, there is limited information regarding muscle power derived from the 30-s STS test, a widely used test in the clinical setting. This study aimed (i) to compare relative 30-s STS power values between older men and women, (ii) to identify cut-off points for low relative 30-s STS power, (iii) to compare the prevalence of low relative STS power between sexes and (iv) to evaluate the association of low relative 30-s STS power with adverse conditions in older people.
Methods: A total of 1475 community-dwelling older adults (65-98 years; 45% men) from the Toledo Study for Healthy Aging were included.
Identification of risk factors and development of a predictive nomogram for sarcopenia in Alzheimer's disease.
Alzheimers Dement
January 2025
Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Introduction: Sarcopenia, with its complex diagnostic process, is a likely independent predictor of poor prognosis in patients with Alzheimer's disease (AD). However, research on the clinical characteristics and biomarkers of AD patients with sarcopenia (ADSA) is limited.
Methods: This study included 180 ADSA and 188 AD patients without sarcopenia (ADNSA), and evaluated demographics, cognitive function, motor capacity, emotional state, and daily living abilities.
Exploring the Connections Between Grip Strength, Nutritional Status, Frailty, Depression, and Cognition as Initial Assessment Tools in Geriatric Rehabilitation-A Pilot Study.
Medicina (Kaunas)
November 2024
Doctoral School, University of Medicine and Pharmacy Carol Davila, Dionisie Lupu Street, No. 37, Sector 2, 020021 Bucharest, Romania.
In the context of the rapidly aging global population, the older adult vulnerability poses a significant challenge for public health systems. Frailty, cognitive and nutritional status, depression, and grip strength are essential parameters for staging the vulnerability of older adults. The objective of this study is to identify a rapid but multidimensional geriatric assessment tool that can enhance the rehabilitation process for older adults, tailored to their specific needs.
View Article and Find Full Text PDFPhysical Activity and Frailty Are Impaired in Older Adults with Benign Paroxysmal Positional Vertigo.
J Clin Med
December 2024
Faculty of Rehabilitation Sciences, REVAL-Rehabilitation Research Centre, Hasselt University, 3590 Diepenbeek, Belgium.
: Benign Paroxysmal Positioning Vertigo (BPPV), diagnosed in 46% of older adults with complaints of dizziness, causes movement-related vertigo. This case-control study compared physical activity, frailty and subjective well-being between older adults with BPPV (oaBPPV) and controls. : Thirty-seven oaBPPV (mean age 73.
View Article and Find Full Text PDFThe disease burden of earlier and late-onset rheumatoid arthritis on depression and related geriatric syndromes.
Psychogeriatrics
January 2025
Kastamonu Training and Research Hospital, Division of Rheumatology, University of Health Sciences, Kastamonu, Turkey.
Purpose: This study aims to compare the prevalence of depression and related geriatric syndromes in earlier-onset rheumatoid arthritis (EORA) patients, who have experienced prolonged inflammation and medication use, with those with late-onset rheumatoid arthritis (LORA) patients, who often present with an acute and severe course.
Methods: In this multidisciplinary study, patients with EORA and LORA aged 60 and over who were referred to a tertiary rheumatology clinic underwent a geronto-rheumatologic evaluation. Muscle mass and handgrip strength, cognitive function, nutritional status, Fried frailty index, fall history, gait speed, depression according to Geriatric Depression Scale and Insomnia Severity Index were recorded.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!