AI Article Synopsis
- Researchers studied the effectiveness of high-dose dual antibiotic-loaded bone cement (ALBC) versus single ALBC in reducing the risk of re-revision after total hip and knee replacements.
- Using data from the Dutch Arthroplasty Register, they analyzed over 9,600 patients who underwent their first cemented aseptic hip or knee revisions between 2007 and 2018.
- The study found no significant differences in re-revision rates or implant survival between single and dual ALBC, indicating that dual ALBC may not offer additional benefits.
Article Abstract
Background And Purpose: High-dose dual antibiotic-loaded bone cement (ALBC) may reduce the risk of revision after total hip and knee replacements. The aim of our study therefore was to determine the risk of re-revision following first time aseptic hip or knee revision using single versus dual ALBC.
Patients And Methods: Patients from the Dutch Arthroplasty Register treated from 2007 to 2018 with first time cemented aseptic hip (n = 2,529) or knee revisions (n = 7,124) were incorporated into 2 datasets. The primary endpoint of this observational cohort study was subsequent all-cause re-revision. Multivariable Cox proportional hazard and competing risk was analyzed for both groups.
Results: There was no difference in re-revision rate (any reason) with single versus dual ALBC (hazard ratio 1.06, 95% confidence interval [CI] 0.83-1.35 for hip and 0.93, CI 0.80-1.07 for knee revisions). The 10-year crude cumulative re-revision rate also showed no differences for single versus dual ALBC use. The crude cumulative 7-year THA re-revision and 9-year TKA re-revision rates did not show any difference in implant survival for common cement types used.
Conclusion: We could not confirm the potential benefit of using dual ALBC compared with single ALBC for aseptic hip and knee revisions.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510150 | PMC |
| http://dx.doi.org/10.2340/17453674.2023.18645 | DOI Listing |
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