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Association of intraoperative cerebral and somatic tissue oxygen saturation with postoperative acute kidney injury in adult patients undergoing multiple valve surgery. | LitMetric

AI Article Synopsis

  • This study explored the link between tissue oxygen levels and postoperative acute kidney injury (AKI) in patients undergoing multiple valve surgeries, enrolling 99 participants.
  • Researchers monitored oxygen saturation in various body tissues and assessed different threshold levels to see their correlation with AKI occurrence, which affected 54% of the patients.
  • The findings suggest that significant drops in tissue oxygen saturation below certain thresholds might be related to AKI, but further research is needed to confirm these results in larger populations.

Article Abstract

Background: The association between tissue oxygenation with postoperative acute kidney injury (AKI) in adult patients undergoing multiple valve surgery has not been specifically studied.

Methods: In this prospective exploratory cohort study, 99 patients were enrolled. The left forehead, the left forearm, the left upper thigh, and the left renal region tissue oxygen saturation using near-infrared spectroscopy were monitored. The association between each threshold and AKI was assessed. The relative and absolute thresholds were < 70%, < 75%, < 80%, < 85%, < 90%, < 95%, and < 100% baseline, and baseline-standard deviation (SD), -1.5 SD, -2 SD, -2.5 SD, and -3 SD. Multivariate logistic regression analysis was adopted to explore the association.

Results: AKI occurred in 53 (54%) patients. The absolute value-based SrrO2 thresholds associated with AKI were baseline-3 SD (odds ratio [OR], 4.629; 95% confidence interval [CI], 1.238-17.314; P = 0.023) and baseline-2.5 SD (OR, 2.842; 95% CI, 1.025-7.881; P = 0.045) after adjusting for the potential confounders, those are renal region tissue oxygen saturation of 55% and 60%, but not statistically significant after correcting for multiple testing (corrected P = 0.114 and 0.179, respectively).

Conclusion: The SrrO2 desaturation, defined as < baseline - 2.5 SD or < baseline - 3 SD, may be associated with AKI. The thresholds need to be verified in future large-scale studies.

Trial Registrations: The study was registered at ClinicalTrials.gov, first trial registration: 26/10/2017, identifier: NCT03323203.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507988PMC
http://dx.doi.org/10.1186/s12871-023-02279-7DOI Listing

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