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The biocide triclosan as a potential developmental disruptor in Mytilus early larvae. | LitMetric

The biocide triclosan as a potential developmental disruptor in Mytilus early larvae.

Environ Sci Pollut Res Int

Department of Earth, Environmental and Life Sciences-DISTAV, University of Genoa, Genoa, Italy.

Published: October 2023

AI Article Synopsis

Article Abstract

The broadly utilized biocide triclosan (TCS) is continuously discharged in water compartments worldwide, where it is detected at concentrations of ng-µg/L. Given its lipophilicity and bioaccumulation, TCS is considered potentially harmful to human and environmental health and also as a potential endocrine disruptor (ED) in different species. In aquatic organisms, TCS can induce a variety of effects: however, little information is available on its possible impact on invertebrate development. Early larval stages of the marine bivalve Mytilus galloprovincialis have been shown to be sensitive to environmental concentrations of a number of emerging contaminants, including EDs. In this work, the effects of TCS were first evaluated in the 48 h larval assay in a wide concentration range (0.001-1,000 μg/L). TCS significantly affected normal development of D-veligers (LOEC = 0.1 μg/L; EC = 236.1 μg/L). At selected concentrations, the mechanism of action of TCS was investigated. TCS modulated transcription of different genes involved in shell mineralization, endocrine signaling, ceramide metabolism, and biotransformation, depending on larval stage (24 and 48 h post-fertilization-hpf) and concentration (1 and 10 μg/L). At 48 hpf and 10 μg/L TCS, calcein staining revealed alterations in CaCO deposition, and polarized light microscopy showed the absence of shell birefringence due to the mineralized phase. Observations by scanning electron microscopy highlighted a variety of defects in shell formation from concentrations as low as 0.1 μg/L. The results indicate that TCS, at environmental exposure levels, can act as a developmental disruptor in early mussel larvae mainly by interfering with the processes of biomineralization.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579167PMC
http://dx.doi.org/10.1007/s11356-023-29854-2DOI Listing

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