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Elastic fiber alterations and calcifications in calcific uremic arteriolopathy. | LitMetric

AI Article Synopsis

  • Calcific uremic arteriolopathy (CUA) is a serious condition mainly affecting patients with end-stage renal disease (ESRD) on dialysis, marked by calcium deposits in the skin.
  • A study compared the elastic fiber structure and skin calcifications in 14 ESRD patients with CUA to 12 without using advanced imaging techniques.
  • The findings revealed significant differences in elastic fiber fragmentation and the presence of massive circumferential vascular calcifications in CUA patients, suggesting these features might indicate a more specific link to CUA compared to general calcifications seen in other ESRD patients.

Article Abstract

Calcific uremic arteriolopathy (CUA) is a severely morbid disease, affecting mostly dialyzed end-stage renal disease (ESRD) patients, associated with calcium deposits in the skin. Calcifications have been identified in ESRD patients without CUA, indicating that their presence is not specific to the disease. The objective of this retrospective multicenter study was to compare elastic fiber structure and skin calcifications in ESRD patients with CUA to those without CUA using innovative structural techniques. Fourteen ESRD patients with CUA were compared to 12 ESRD patients without CUA. Analyses of elastic fiber structure and skin calcifications using multiphoton microscopy followed by machine-learning analysis and field-emission scanning electron microscopy coupled with energy dispersive X-ray were performed. Elastic fibers specifically appeared fragmented in CUA. Quantitative analyses of multiphoton images showed that they were significantly straighter in ESRD patients with CUA than without CUA. Interstitial and vascular calcifications were observed in both groups of ESRD patients, but vascular calcifications specifically appeared massive and circumferential in CUA. Unlike interstitial calcifications, massive circumferential vascular calcifications and elastic fibers straightening appeared specific to CUA. The origins of such specific elastic fiber's alteration are still to be explored and may involve relationships with ischemic vascular or inflammatory processes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509184PMC
http://dx.doi.org/10.1038/s41598-023-42492-5DOI Listing

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