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Annals On Call - Diagnostic Reasoning Part 1.
Ann Intern Med
January 2025
Tufts University School of Medicine, Wellesley, Massachusetts (J.P.K.).
Cardiovascular Safety and Fracture Prevention Effectiveness of Denosumab Versus Oral Bisphosphonates in Patients Receiving Dialysis : A Target Trial Emulation.
Ann Intern Med
January 2025
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan (K.K.).
Background: Dialysis patients have high rates of fracture morbidity, but evidence on optimal management strategies for osteoporosis is scarce.
Objective: To determine the risk for cardiovascular events and fracture prevention effects with denosumab compared with oral bisphosphonates in dialysis-dependent patients.
Design: An observational study that attempts to emulate a target trial.
In subclinical AF, apixaban vs. aspirin reduced stroke or systemic embolism at 3.5 y, regardless of duration of recent subclinical AF episodes.
Ann Intern Med
January 2025
University of Michigan, Ann Arbor, Michigan, USA (E.R.B.).
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].
View Article and Find Full Text PDFAssessing the Risk for Falls in Older Adults After Initiating Gabapentin Versus Duloxetine.
Ann Intern Med
January 2025
Center for Healthcare Delivery Sciences, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (R.J.D., N.K.C., N.H., J.C.L.).
Background: The evidence informing the harms of gabapentin use are at risk of bias from comparing users with nonusers.
Objective: To describe the risk for fall-related outcomes in older adults starting treatment with gabapentin versus duloxetine.
Design: New user, active comparator study using a target trial emulation framework.
In T1D, weekly efsitora was noninferior to daily degludec for reducing HbA but increased severe hypoglycemia at 26 wk.
Ann Intern Med
January 2025
Mayo Clinic, Rochester, Minnesota, USA (F.L., M.R.G., V.M.M.).
Endocrinology: [Formula: see text].
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