Unveiling pseudo-pulseless electrical activity (pseudo-PEA) in ultrasound-integrated infant resuscitation.

Eur J Pediatr

Department of Pediatrics, Division of Neonatology, Loma Linda University School of Medicine, 11175 Coleman Pavilion, Campus Street, Loma Linda, CA, 92354, USA.

Published: December 2023

AI Article Synopsis

  • Point-of-care ultrasound (POCUS) is being increasingly utilized in neonatal intensive care units (NICUs) to aid in diagnosing life-threatening emergencies, particularly in critically deteriorating infants.
  • New protocols like SAFE-R and CNP provide detailed steps for identifying reversible causes of cardiorespiratory collapse, including the concept of pseudo-PEA—where cardiac motion exists but does not create a detectable pulse.
  • The article reviews adult literature on pseudo-PEA to improve neonatal resuscitation strategies and calls for better integration of POCUS in these emergency protocols to enhance outcomes for infants.

Article Abstract

Unlabelled: Point-of-care ultrasound (POCUS) holds immense potential to manage critically deteriorating infants within the neonatal intensive care unit (NICU) and is increasingly used in neonatal clinical practice worldwide. Recent ultrasound-based protocols such as the Sonographic Assessment of liFe-threatening Emergencies-Revised (SAFE-R) and Crashing Neonate Protocol (CNP) offer step-by-step guidance for diagnosing and addressing reversible causes of cardiorespiratory collapse. Traditionally, pulseless electrical activity (PEA) has been diagnosed solely based on absent pulses on clinical examination, disregarding myocardial activity. However, integrating POCUS into resuscitation unveils the concept of pseudo-PEA, where cardiac motion activity is observed visually on the ultrasound but fails to generate a detectable pulse due to inadequate cardiac output. Paradoxically, existing neonatal resuscitation protocols lack directives for identifying and effectively leveraging pseudo-PEA insights in infants, limiting their potential to enhance outcomes. Pseudo-PEA is extensively described in adult literature owing to routine POCUS use in resuscitation. This review article comprehensively evaluates the adult pseudo-PEA literature to glean insights adaptable to neonatal care. Additionally, we propose a simple strategy to integrate POCUS during neonatal resuscitation, especially in infants who do not respond to routine measures.

Conclusion: Pseudo-PDA is a newly recognized diagnosis in infants with the use of POCUS during resuscitation. This article highlights the importance of cross-disciplinary learning in tackling emerging challenges within neonatal medicine.

What Is Known: • Point-of-Care ultrasound (POCUS) benefits adult cardiac arrest management, particularly in distinguishing true Pulseless Electrical Activity (PEA) from pseudo-PEA. • Pseudo-PEA is when myocardial motion can be seen on ultrasound but fails to generate palpable pulses or sustain circulation despite evident cardiac electrical activity.

What Is New: • Discuss recognition and management of pseudo-PEA in infants. • A proposed algorithm to integrate POCUS into active neonatal cardiopulmonary resuscitation (CPR) procedures.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10746595PMC
http://dx.doi.org/10.1007/s00431-023-05199-3DOI Listing

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