Langya henipavirus outbreak.

Expert Rev Anti Infect Ther

Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Published: November 2023

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http://dx.doi.org/10.1080/14787210.2023.2260561DOI Listing

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In 2022, Langya henipavirus was identified in patients with fever in eastern China. This study provides an overview of the scientific landscape, highlights research focus areas, and outlines potential future investigations. The relevant scientific literature was systematically searched and reviewed via advanced bibliometric techniques.

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HRP-integrated CRISPR-Cas12a biosensor for rapid point-of-care detection of Langya henipavirus.

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December 2024

Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), School of Laboratory Medicine, Chongqing Medical University, 1 Xueyuan Road, Chongqing 400016, China.

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  • The COVID-19 pandemic revealed the urgent need for better diagnostic tools to quickly identify new infectious diseases, such as Langya henipavirus (LayV).
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(HNVs), a genus within the family, includes the highly virulent Nipah and Hendra viruses that cause yearly reoccurring outbreaks of deadly disease. Recent discoveries of several new species, including the zoonotic Langya virus, have revealed much higher antigenic diversity than currently characterized. Here, to explore the limits of structural and antigenic variation in HNVs, we construct an expanded, antigenically diverse panel of HNV fusion (F) and attachment (G) glycoproteins from 56 unique HNV strains that better reflects global HNV diversity.

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This study reports the identification of Langya virus Korea (LayV KOR) during the surveillance of shrews in the Republic of Korea. LayV KOR represents the first identification of LayV outside of China, exhibiting approximately 80% and 95.5% homologies at nucleotide and amino acid levels.

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Article Synopsis
  • * Over 190 different viruses in 32 families have been found in shrews, some of which can cause diseases in both humans and animals.
  • * The review aims to provide essential information on shrews and their viruses to help raise awareness about the potential health risks they pose to public and animal health.
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