AI Article Synopsis
- Non-alcoholic steatohepatitis (NASH) is becoming a leading cause of liver cancer, specifically hepatocellular carcinoma (HCC), especially in individuals with metabolic syndrome.
- The exact mechanisms behind how NASH leads to HCC are not fully understood, prompting further research into genetic alterations and the immune environment associated with this type of cancer.
- Recent studies suggest that NASH-related HCC may involve unique processes that require additional investigation to uncover their complexities.*
Article Abstract
Non-alcoholic steatohepatitis (NASH) with metabolic syndrome is increasing to be a main cause of hepatocellular carcinoma (HCC). However, the mechanism of tumorigenesis in NASH induced HCC is still not clear. In this perspective, we will discuss the recent progress that has been made to understand the genetic change and the immune microenvironment of HCC, and the remaining questions. Based on the current study, NASH-HCC is likely to have novel mechanism, which needs more investigation in future.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471092 | PMC |
| http://dx.doi.org/10.1515/mr-2022-0043 | DOI Listing |
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