AI Article Synopsis
- - Borderline personality disorder (BPD) is a complex mental health issue characterized by instability in mood, relationships, and self-image, with genetic factors playing a significant role in its development and treatment outcomes.
- - Genetic influences account for 40-60% of the variation in BPD, with notable importance of epigenetic changes and gene-environment interactions, especially considering factors like childhood trauma.
- - Effective treatments such as dialectical behavior therapy and mentalization-based therapy show varied success potentially linked to genetic differences, highlighting the need for future research on diverse populations and personalized medicine approaches for better BPD management.
Article Abstract
Borderline personality disorder (BPD) manifests as instability in mood, relationships, self-image, and behavior, representing a challenging mental health issue. This review scrutinizes genetic factors influencing BPD and the corresponding treatment outcomes. The primary objective of this narrative review is to illuminate the association between genetic factors and BPD treatment outcomes, discussing the potential of genetic testing for personalized therapy. The review is derived from observational and experimental studies on BPD, genetic factors, and psychotherapy from 2000 to 2023, sourced primarily through PubMed. Reviews and meta-analyses were excluded. Our review suggests that genetic factors account for 40-60% of BPD variation, with significant roles played by epigenetic alterations like DNA methylation and microRNAs, particularly in the context of childhood trauma. Gene-environment interactions are also vital for BPD's development. Treatments such as dialectical behavior therapy, mentalization-based therapy, and schema therapy have shown efficacy, with success variability possibly linked to genetic factors. However, existing research is constrained by recall bias, diverse methodologies, and limited sample sizes. Future research necessitates long-term follow-up, diverse populations, and controlled variables to enhance our comprehension of BPD treatment outcomes' genetic foundations. The review underlines the promise of personalized medicine in BPD treatment, driven by genetic insights.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505449 | PMC |
| http://dx.doi.org/10.7759/cureus.43702 | DOI Listing |
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