Objective: This study aimed to assess the association of shift work with blood glucose and the mediating role of oxidative stress.
Methods: Fasting plasma glucose (FPG) and urinary concentrations of oxidative stress biomarkers (8-hydroxy-2'-deoxyguanosine [8-OHdG], 4-hydroxy-2-nonenal-mercapturic acid, and 8-iso-prostaglandin F [8-isoPGF ]) were measured among 831 participants.
Results: Positive dose-response relationships among shift work duration, FPG (p < 0.001), and abnormal glucose regulation (AGR; p = 0.035) were found. Compared with participants without shift work, three-shift work was associated with a higher level of FPG (percentage change: 6.49%, 95% CI: 4.21%-8.83%) and a higher prevalence of impaired fasting glucose (odds ratio: 1.886, 95% CI: 1.114-3.192) and AGR (odds ratio: 1.929, 95% CI: 1.197-3.111). A dose-response relationship was found between shift work duration and 8-OHdG (p = 0.002) and 8-isoPGF (p = 0.019). Urinary 8-OHdG and 8-isoPGF partially mediated the association between shift work duration and FPG levels and the prevalence of impaired fasting glucose and AGR, with mediating proportions ranging from 4.77% to 20.76%.
Conclusions: These findings suggest that shift work is positively associated with blood glucose, and the association is partially mediated by oxidative stress.
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