We study transition paths in energy landscapes over multicategorical Potts configurations using the mean-field approach introduced by Mauri et al. [Phys. Rev. Lett. 130, 158402 (2023)0031-900710.1103/PhysRevLett.130.158402]. Paths interpolate between two fixed configurations or are anchored at one extremity only. We characterize the properties of "good" transition paths realizing a trade-off between exploring low-energy regions in the landscape and being not too long, such as their entropy or the probability of escape from a region of the landscape. We unveil the existence of a phase transition separating a regime in which paths are stretched in between their anchors from another regime where paths can explore the energy landscape more globally to minimize the energy. This phase transition is first illustrated and studied in detail on a mathematically tractable Hopfield-Potts toy model, then studied in energy landscapes inferred from protein sequence data.
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http://dx.doi.org/10.1103/PhysRevE.108.024141 | DOI Listing |
Lakartidningen
January 2025
docent, institutionen för klinisk neuro-vetenskap, Karolins-ka institutet.
There are four paths to a Swedish medical license. A shared agreement exists for those converting from a European license to recognize qualifications granted in the respective countries mutually. Swedish medical graduates and International Medical Graduates (IMGs) trained outside the EU/EES/Schweiz are assessed against the professional qualifications specified in the Higher Education Ordinance (1993:100).
View Article and Find Full Text PDFJ Couns Psychol
January 2025
School of Marxism, Central University of Finance and Economics.
Rural first-generation college students (FGCS) face significant barriers as they transition into the world of work, yet no studies have explored their career development using psychology of working theory (PWT). The present study aimed to examine the predictor and outcome portions of PWT with a sample of FGCS from rural China. We administered online surveys to 549 participants and employed structural equation modeling to analyze the data.
View Article and Find Full Text PDFNat Commun
January 2025
School of Environmental and Chemical Engineering, Wuyi University, Jiangmen, PR China.
Developing efficient strategies for the deoxygenative functionalization of carbonyl compounds is crucial for enhancing the effective utilization of biomass and the upgrading of chemical feedstocks. In this study, we present an elegant cathodic reduction strategy that enables a tandem alkylation/dearomatization reaction between quinoline derivatives and aryl aldehydes/ketones in a one-pot process. Our approach can be executed via two distinct paths: the aluminum (Al)-facilitated spin-center shift (SCS) path and the Al-facilitated direct deoxygenation path.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Chemistry, New York University, New York, NY 10003.
Frameshifting is an essential mechanism employed by many viruses including coronaviruses to produce viral proteins from a compact RNA genome. It is facilitated by specific RNA folds in the frameshift element (FSE), which has emerged as an important therapeutic target. For SARS-CoV-2, a specific 3-stem pseudoknot has been identified to stimulate frameshifting.
View Article and Find Full Text PDFFront Sports Act Living
January 2025
Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy.
Introduction: In the so-called "new career era," career transitions and employability have attracted growing attention. For elite athletes, the Dual Career experiences may be regarded as a protective factor during various career transitions, with the end-of-career transition being closely linked to employability. This contribution aims to explore the dual career paths of athletes through the lens of graduate employability, as perceived by the individuals themselves.
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