AI Article Synopsis
- - This study focused on understanding factors that influence fever and the duration of fever in young children with bacterial meningitis (BM), involving data from 49 centers in China over a span of more than two years.
- - A total of 863 patients under three years old were analyzed, revealing that certain infections like coagulase negative staphylococcus led to less fever, while conditions such as septicaemia and ear-nose-throat infections were linked to higher fever rates.
- - The research identified specific factors associated with delayed fever resolution, including infections like Streptococcus agalactiae, gastrointestinal infections, and complications such as encephalomalacia and subdural effusion, which could help in diagnosing and monitoring the severity of the
Article Abstract
Background: This multi-center study aimed to identify factors affecting fever and delayed defervescence in bacterial meningitis (BM) patients under 3 years of age because of the variability of fever in this patient population.
Methods: Only BM patients under 3 years treated at 49 centers in China from November 2018 to end-April 2021 were included in the study. Univariate and multivariate logistic regression analyses were performed to determine factors associated with afebrile presentation and fever of delayed defervescence.
Results: A total of 863 BM patients under 3 years were included in the study. Coagulase negative staphylococcus was associated with afebrile presentation (OR = 1.176), while septicaemia and ear-nose-throat infections were associated with fever (P < 0.05). The patients with fever were assigned into early and delayed defervescence groups based on defervescence time (less than and more than or equal to one week). Furthermore, Streptococcus agalactiae meningitis (OR = 1.124), concomitant gastrointestinal infection (OR = 1.276), encephalomalacia (or = 1.339), and subdural effusion (OR = 1.454) were independently associated with delayed defervescence (all P < 0.05).
Conclusions: The findings can aid in the efficient utilization of fever in auxiliary diagnosis and evaluating the condition of the disease.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507889 | PMC |
| http://dx.doi.org/10.1186/s12887-023-04179-8 | DOI Listing |
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