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Treatments for COVID-19. | LitMetric

Treatments for COVID-19.

Annu Rev Med

Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA; email:

Published: January 2024

AI Article Synopsis

  • * Antivirals are most effective when given early for mild cases, while immunomodulatory drugs are better suited for severe cases.
  • * The effectiveness of monoclonal antibodies has decreased due to new viral variants, and ongoing studies aim to potentially change treatment strategies in the future.

Article Abstract

The treatment for COVID-19 has evolved rapidly since the start of the pandemic and now consists mainly of antiviral and immunomodulatory agents. Antivirals, such as remdesivir and nirmatrelvir-ritonavir, have proved to be most useful earlier in illness (e.g., as outpatient therapy) and for less severe disease. Immunomodulatory therapies, such as dexamethasone and interleukin-6 or Janus kinase inhibitors, are most useful in severe disease or critical illness. The role of anti-SARS-CoV-2 monoclonal antibodies has diminished because of the emergence of viral variants that are not anticipated to be susceptible to these treatments, and there still is not a consensus on the use of convalescent plasma. COVID-19 has been associated with increased rates of venous thromboembolism, but the role of antithrombotic therapy is limited. Multiple investigational agents continue to be studied, which will alter current treatment paradigms as new data are released.

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Source
http://dx.doi.org/10.1146/annurev-med-052422-020316DOI Listing

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