AI Article Synopsis
- The study explores the use of food-grade hexosomes (HEXs) as carriers for a fish-purified antioxidant peptide (PF10), showing that they can encapsulate the peptide efficiently and sustain its release over time.
- The HEXs were characterized using techniques like SAXS and cryo-TEM, revealing that PF10 influences their structure based on pH levels.
- Antioxidant tests demonstrated that these nano-self-assemblies effectively preserve the activity of PF10, even though both the free peptide and the encapsulated version show reduced antioxidant capacity in simulated gastrointestinal conditions.*
Article Abstract
Herein, we describe the potential use of food-grade hexosomes (HEXs) for delivering fish-purified antioxidant peptide (PF10). Using a binary lipid mixture of Dimodan U/citrem, the nanocarriers were produced with a size range of 202.7-569.8 nm and peptide encapsulation efficiency of 64.6-89.3%. These HEXs were also characterized by SAXS and cryo-TEM, and were able to sustain the release of PF10, where only 32.2% released in PBS after 24 h. SAXS findings verified that PF10 modulate the internal structure of HEXs in a pH-dependent manner. Antioxidant assays proved the efficacy of such nano-self-assemblies in maintaining the bioactivity of the loaded peptide. Moreover, the in vitro gastrointestinal stability test indicated that the antioxidant capacity of the free- and PF10-loaded HEXs decreased under SGF/SIF conditions with the reduction in activity being greater for the free PF10. The present findings may provide a useful basis for development of pH-responsive nano-self-assemblies for delivery of antioxidant peptides.
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| http://dx.doi.org/10.1016/j.foodchem.2023.137446 | DOI Listing |
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Article Synopsis
- The study explores the use of food-grade hexosomes (HEXs) as carriers for a fish-purified antioxidant peptide (PF10), showing that they can encapsulate the peptide efficiently and sustain its release over time.
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