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Background: Use of the supratentorial white matter (sWM) as a reference region for amyloid PET, alone or in a composite, can facilitate the detection of subtle changes in amyloid load (Wong et al., 2010; Landau et al., 2015).
View Article and Find Full Text PDFThe Impact of MRI-Defined Extent of Resection Across Meningioma DNA Methylation Groups: Re-Evaluating Surgery in the Era of Meningioma Molecular Classification.
Neurosurgery
January 2025
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Background And Objectives: Extent of resection (EOR) is prognostic for meningioma outcomes. DNA methylation profiling can shed light on biological drivers and therapeutic vulnerabilities. The goal of this study was to re-evaluate the impact of EOR on clinical outcomes across meningioma DNA methylation groups.
View Article and Find Full Text PDFSustained-Release Solid Dispersions of Fenofibrate for Simultaneous Enhancement of the Extent and Duration of Drug Exposure.
Pharmaceutics
December 2024
College of Pharmacy, Dongguk University-Seoul, Dongguk-ro-32, Ilsan-Donggu, Goyang 10326, Republic of Korea.
Background/objectives: A sustained-release formulation of fenofibrate while enhancing drug dissolution with minimal food effect is critical for maximizing the therapeutic benefits of fenofibrate. Therefore, this study aimed to develop an effective solid dispersion formulation of fenofibrate for simultaneous enhancement in the extent and duration of drug exposure.
Methods: Fenofibrate-loaded solid dispersions (FNSDs) were prepared using poloxamer 407 and Eudragit RSPO at varied ratios via solvent evaporation.
Trait Anxiety Leads to "Better" Performance? A Study on Acute Stress and Uncertain Decision-Making.
Behav Sci (Basel)
December 2024
Department of Military Medical Psychology, Air Force Medical University, Xi'an 710032, China.
In uncertain situations, individuals seek to maximize rewards while managing risks. Yet, the effects of acute stress and anxiety on decision-making in ambiguous and risky contexts are unclear. This study aims to contribute to the exploration of how acute stress influences sensitivity to immediate vs.
View Article and Find Full Text PDFChanging the Paradigm for Tractography Segmentation in Neurosurgery: Validation of a Streamline-Based Approach.
Brain Sci
December 2024
Neuroinformatics Laboratory (NiLab), Bruno Kessler Foundation (FBK), 39123 Trento, Italy.
In glioma surgery, maximizing the extent of resection while preserving cognitive functions requires an understanding of the unique architecture of the white matter (WM) pathways of the single patient and of their spatial relationship with the tumor. Tractography enables the reconstruction of WM pathways, and bundle segmentation allows the identification of critical connections for functional preservation. This study evaluates the effectiveness of a streamline-based approach for bundle segmentation on a clinical dataset as compared to the traditional ROI-based approach.
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