AI Article Synopsis
- - Dipeptidyl peptidase-like protein 9 (DPP9) is gaining attention as a potential drug target for treating blood-related diseases.
- - Two new DPP9 inhibitors have been developed that are highly effective (nanomolar affinity) and specifically target DPP9 rather than the similar protein DPP8.
- - This discovery opens up new avenues for advancing treatments that utilize DPP9's role in healthcare.
Article Abstract
Dipeptidyl peptidase-like protein 9 (DPP9) is emerging as a promising drug target for the treatment of hematological diseases. Two novel DPP9 inhibitors with nanomolar affinity and unprecedented selectivity to DPP9 over DPP8 have been discovered, paving the way for future progress in DPP9-mediated treatments.
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| http://dx.doi.org/10.1021/acs.jmedchem.3c01631 | DOI Listing |
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