AI Article Synopsis
- - Planarians are primitive bilateral triploblastic animals with a remarkable ability to regenerate their bodies, including their brain-like structures, making them key subjects in regenerative research for over 240 years.
- - Recent research highlights the importance of accurate cell communication for regeneration, with stem cells (neoblasts) identified as the main source of new cells required for both normal maintenance and regeneration processes.
- - The review explores breakthroughs in understanding how neoblasts interact with other cell types during regeneration, while also addressing ongoing challenges and future research directions in the field of planarian regeneration.
Article Abstract
Planarians represent the most primitive bilateral triploblastic animals. Most planarian species exhibit mechanisms for whole-body regeneration, exemplified by the regeneration of their cephalic ganglion after complete excision. Given their robust whole-body regeneration capacity, planarians have been model organisms in regenerative research for more than 240 years. Advancements in research tools and techniques have progressively elucidated the mechanisms underlying planarian regeneration. Accurate cell-cell communication is recognized as a fundamental requirement for regeneration. In recent decades, mechanisms associated with such communication have been revealed at the cellular level. Notably, stem cells (neoblasts) have been identified as the source of all new cells during planarian homeostasis and regeneration. The interplay between neoblasts and somatic cells affects the identities and proportions of various tissues during homeostasis and regeneration. Here, this review outlines key discoveries regarding communication between stem cell compartments and other cell types in planarians, as well as the impact of communication on planarian regeneration. Additionally, this review discusses the challenges and potential directions of future planarian research, emphasizing the sustained impact of this field on our understanding of animal regeneration.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559094 | PMC |
| http://dx.doi.org/10.24272/j.issn.2095-8137.2023.044 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance.
Nat Commun
December 2024
Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
Tissue regeneration is a complex process involving large changes in cell proliferation, fate determination, and differentiation. Mitochondrial dynamics and metabolism play a crucial role in development and wound repair, but their function in large-scale regeneration remains poorly understood. Planarians offer an excellent model to investigate this process due to their remarkable regenerative abilities.
View Article and Find Full Text PDFFoxO is required for neoblast differentiation during planarian regeneration.
Int J Biol Macromol
December 2024
Laboratory of Tissue Engineering, College of Life Sciences, Northwest University, Xi'an, China; Provincial Key Laboratory of Biotechnology of Shaanxi, Northwest University, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an, China. Electronic address:
Stem cells are of great importance in the maintenance and regeneration of tissues, with Forkhead box O (FoxO) proteins emerging as pivotal regulators of their functions. However, the precise impact of FoxO proteins on stem cell behavior within regenerative environments remains ambiguous. Planarians, renowned for their abundance of adult stem cells (neoblasts), serve as an excellent model for investigating the dynamics of stem cells during regeneration.
View Article and Find Full Text PDFVerification of radical pair mechanism predictions for weak magnetic field effects on superoxide in planarians.
bioRxiv
November 2024
Department of Physics and Astronomy, University of Calgary, Calgary, Alberta, Canada.
Superoxide concentration and tissue regeneration in planarians exhibit a complex non-monotonic dependence on the strength of an applied weak magnetic field. While this is difficult to understand based on classical physics, a recently proposed quantum model based on a flavin-superoxide radical pair mechanism could replicate the previously observed superoxide concentrations. However, this model also predicts increased superoxide concentrations for both lower and higher fields.
View Article and Find Full Text PDFNature's Secret Neuro-Regeneration Pathway in Axolotls, Polychaetes and Planarians for Human Therapeutic Target Pathways.
Int J Mol Sci
November 2024
Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, Malaysia.
Article Synopsis
- Restoring nerve injury in humans is challenging, especially in the central nervous system (CNS), where factors like glial scars hinder regeneration compared to the peripheral nervous system (PNS), which relies on Schwann cells for support.
- Unlike humans, some species like axolotls and planarians can regenerate their nervous systems thanks to abundant pluripotent stem cells that can differentiate into various cell types.
- Understanding the molecular pathways of these regenerating species may provide insights and new strategies for improving nerve regeneration therapies in humans.
Fibrillarin homologs regulate translation in divergent cell lineages during planarian homeostasis and regeneration.
EMBO J
December 2024
Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
Tissue homeostasis and regeneration involve complex cellular changes. The role of rRNA modification-dependent translational regulation in these processes remains largely unknown. Planarians, renowned for their ability to undergo remarkable tissue regeneration, provide an ideal model for the analysis of differential rRNA regulation in diverse cell types during tissue homeostasis and regeneration.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!