Exposure to ionizing radiation can also lead to the formation of stable or unstable radicals in the structures of drugs, as in many materials. The concentrations of these radicals may show a linear dependence on the radiation dose exposed. Since drugs are materials that can be found next to or on radiation victims during a possible nuclear or radiological accident, it is very meaningful to determine the Electron Paramagnetic Resonance (EPR) dosimetric properties of stable radicals in their structures. In this study, the dosimetric properties of Famoser, which is one of the stomach-relieving drugs that people often have with them in their daily life, in the dose range of 10-800 Gy were investigated by EPR technique.
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http://dx.doi.org/10.1093/rpd/ncad041 | DOI Listing |
J Am Chem Soc
January 2025
Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China.
A small but growing set of radical SAM (-adenosyl-l-methionine) enzymes catalyze the radical mediated dehydration or dehydrogenation of 1,2-diol substrates. In some cases, these activities can be interchanged via minor structural perturbations to the reacting components raising questions regarding the relative importance of hyperconjugation, proton circulation and leaving group stability in determining the reaction outcome. The present work describes trapping and electron paramagnetic resonance (EPR) characterization of an α-hydroxyalkyl radical intermediate during dehydration and dehydrogenation of cytosylglucuronic acid and its derivatives catalyzed by the radical SAM enzyme BlsE and its Glu189Ala mutant from the blasticidin S biosynthetic pathway.
View Article and Find Full Text PDFPharmaceutics
January 2025
Faculty of Pharmacy, "Grigore. T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Magnolol (MG) and honokiol (HK) are bioactive compounds extracted from and trees with significant pharmacological properties, including antioxidant and antibacterial activity. However, their poor water solubility and low bioavailability limit the therapeutic potential. To address these limitations, this study aims to develop MG and HK formulations by co-electrospinning using custom-synthesized β-cyclodextrin-oligolactide (β-CDLA) derivatives.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
School of Civil Engineering and Environmental Science, University of Oklahoma, 202 W Boyd St., Norman, OK 73019, USA.
With 3D printing technology, fiber-reinforced polymer composites can be printed with radical shapes and properties, resulting in varied mechanical performances. Their high strength, light weight, and corrosion resistance are already advantages that make them viable for physical civil infrastructure. It is important to understand these composites' behavior when used in concrete, as their association can impact debonding failures and overall structural performance.
View Article and Find Full Text PDFPharmaceuticals (Basel)
January 2025
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Background: Abel () is widely cultivated and serves as an important source of edible oil. Yet, during oil production, pruned branches generate significant waste and contribute to environmental pollution.
Objectives: In this work, we obtain a natural polysaccharide from the branches of and optimize its extraction using Box-Behnken design (BBD), which is a statistical method commonly used in response surface methodology.
Molecules
January 2025
Organization for Marine Science and Technology, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
High-Density Polyethylene (HDPE) and Low-Density Polyethylene (LDPE) films were used to create nanoplastic (NP) models, with the shape of delamination occurring during degradation. In the case of HDPE, selective degradation occurred not only in the amorphous part, but also in the crystalline part at the same time. Some of the lamellae that extend radially to form the spherulite structure were missing during the 30-day degradation.
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