Absolute thresholds were measured on 27 young (ages 19 to 31) and 21 elderly (ages 55 to 84) humans to six modes of cutaneous stimulation (single ramp-and-hold skin indentations--tactile, vibration at 40 and 250 Hz, temperature increases and decreases, and noxious heat) at two sites, the thenar eminence and the plantar foot. Comparisons of the elderly and young groups showed that elderly persons were significantly, p less than or equal to .001, less sensitive than young individuals to mechanical stimuli (tactile and vibration) at both sites. No significant differences were found in thresholds to thermal stimuli (warm-, cold-, and heat-pain) at either site except elderly feet were significantly, p less than or equal to .001, less sensitive than young feet to warm stimuli. Thresholds of elderly individuals were compared with the young group thresholds for deficits in sensitivity. All elderly participants showed deficits to one or more of the stimulus modes at one or the other site. There were significantly, p less than or equal to 0.01, more deficits to mechanical than to thermal stimuli. There was no increase in the frequency of deficits with increasing age.
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http://dx.doi.org/10.1093/geronj/41.6.732 | DOI Listing |
Iran J Basic Med Sci
January 2025
Faculty of Medical Sciences, Ardabil, Iran.
Objectives: Increased nuclear factor (NF-kβ) and carbonyl stress due to decreased glyoxalase-1 activity (Glo-I) contribute significantly to insulin resistance and vascular complications. Therefore, we aimed to study the impact of the combination of thiamine and niacin on hepatic NF-kβ signaling, metabolic profile, and Glo-I activity in male rats with type-2 diabetes (T2DM).
Materials And Methods: Forty male rats were divided equally into five groups: control, diabetic, diabetic treated with thiamine (180 mg/l in drinking water), niacin (180 mg/l), and a combination of both.
Objectives: To determine the health utility values (HUVs) of overactive bladder (OAB), defined as urinary urgency, usually accompanied by urinary daytime or nocturnal frequency, with or without urinary incontinence, among adults aged ≥65 years and to assess the HUV decrements (disutilities) of OAB according to its severity.
Methods: This cross-sectional Internet-based study was conducted between 2 and 9 November 2023, with quota sampling with equal probability for each sex and age group (age 65-74 years and ≥75 years). OAB was defined as an urgency score of ≥2 points and a total score of ≥3 points based on the Overactive Bladder Symptom Score.
Radiology
January 2025
From the Department of Radiology (J.H.L.) and Department of Thoracic and Cardiovascular Surgery (J.L., Y.J.J., S.Y.P., J.H.C., Y.S.C., J.K., Y.M.S., H.K.K.), Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea; Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, 115 Irwon-ro, Gangnam-gu, Seoul 06355, Korea (D.K., J.L., S.Y.P., S.K., J.C.); Center for Clinical Epidemiology, Sungkyunkwan University, Samsung Medical Center, Seoul, Korea (D.K., J.C.); Patient-Centered Outcomes Research Institute, Samsung Medical Center, Seoul, Korea (J.L., Y.M.S., S.K., H.K.K., J.C.); and Department of Epidemiology and Medicine, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md (J.C.).
Background A comprehensive assessment of skeletal muscle health is crucial to understanding the association between improved clinical outcomes and obesity as defined by body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) in lung cancer, but limited studies have been conducted on this topic. Purpose To investigate the association between BMI-defined obesity and survival in patients with non-small cell lung cancer who underwent curative resection, with a specific focus on the status of skeletal muscle assessed at CT. Materials and Methods This retrospective study investigated Korean patients with non-small cell lung cancer who underwent curative resection between January 2008 and December 2019.
View Article and Find Full Text PDFJSES Rev Rep Tech
February 2025
Department of Orthopaedic Surgery, Henry Ford Hospital, Henry Ford Health, Detroit, MI, USA.
Background: Postresidency training is becoming increasingly common among orthopedic surgeons, with shoulder and elbow surgery growing as a desired subspeciality. There is limited data evaluating how the reputation of an applicants' orthopedic residency influences the outcome of the shoulder and elbow fellowship match. The purpose of this study was to determine if applicants from residencies with better reputation have more favorable odds during the match process compared to applicants from residencies with a less prestigious reputation.
View Article and Find Full Text PDFInt Arch Otorhinolaryngol
January 2025
Department of Ear, Nose and Throat, JJM Medical College, Davangere, Karnataka, India.
Platelet-rich plasma (PRP) contains high platelet concentration and growth factors that help in rapid wound healing, hemostasis, and decreased scarring. It has been used in various conditions to aid in healing, but its use in ear, nose, and throat (ENT) is not yet common. To compare the outcome of using PRP with myringoplasty with that of myringoplasty alone in the repair of tympanic membrane perforations.
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