It is of interest to document the molecular docking analysis of protein Filamin-A with thioazo compounds. The compounds 1, 3, 5, and 6 showed best molecular docking interaction as compared to the drug doxorubicin. Among the selected ligands (1-6), compound 3 shows better interaction score than doxorubicin and follows Lipinski's rule of five. Hence, it could be considered as a potential lead molecule for inhibiting protein filamin A in the treatment of oral cancer.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504497 | PMC |
| http://dx.doi.org/10.6026/97320630019099 | DOI Listing |
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