AI Article Synopsis
- Current whole sporozoite (SPZ) vaccines show limited effectiveness in malaria-endemic regions, possibly due to reduced immune responses from prior malaria exposure.
- Researchers have developed a method to enhance SPZ vaccine immunogenicity by attaching a TLR7 agonist-based adjuvant, leading to significantly higher immune responses, including a 35-fold increase in pro-inflammatory IL-6 production.
- Mice immunized with this enhanced SPZ vaccine demonstrated improved production of specific immune cells, suggesting that this chemical augmentation strategy could make malaria vaccines more effective.
Article Abstract
Despite promising results in malaria-naïve individuals, whole sporozoite (SPZ) vaccine efficacy in malaria-endemic settings has been suboptimal. Vaccine hypo-responsiveness due to previous malaria exposure has been posited as responsible, indicating the need for SPZ vaccines of increased immunogenicity. To this end, we here demonstrate a proof-of-concept for altering SPZ immunogenicity, where supramolecular chemistry enables chemical augmentation of the parasite surface with a TLR7 agonist-based adjuvant (SPZ-SAS(CL307)). , SPZ-SAS(CL307) remained well recognized by immune cells and induced a 35-fold increase in the production of pro-inflammatory IL-6 (p < 0.001). More promisingly, immunization of mice with SPZ-SAS(CL307) yielded improved SPZ-specific IFN-γ production in liver-derived NK cells (percentage IFN-γ cells 11.1 ± 1.8 vs. 9.4 ± 1.5%, p < 0.05), CD4 T cells (4.7 ± 4.3 vs. 1.8 ± 0.7%, p < 0.05) and CD8 T cells (3.6 ± 1.4 vs. 2.5 ± 0.9%, p < 0.05). These findings demonstrate the potential of using chemical augmentation strategies to enhance the immunogenicity of SPZ-based malaria vaccines.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500441 | PMC |
| http://dx.doi.org/10.3389/fimmu.2023.1204606 | DOI Listing |
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