AI Article Synopsis
- ADTKD is a genetic condition linked to chronic kidney disease, but its effects on pregnancy were previously unknown.
- A survey involved 85 women with ADTKD and 23 control women, revealing that few knew about their condition during pregnancy, and highlighting differences in hypertension and preterm births compared to controls.
- Overall, ADTKD pregnancies showed lower hypertension rates than those with other chronic kidney diseases, leading to better health outcomes for mothers and babies.
Article Abstract
Introduction: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized cause of chronic kidney disease. ADTKD pregnancy outcomes have not previously been described.
Methods: A cross-sectional survey was sent to women from ADTKD families.
Results: Information was obtained from 85 afffected women (164 term pregnancies) and 23 controls (50 pregnancies). Only 16.5% of genetically affected women knew they had ADTKD during pregnancy. Eighteen percent of ADTKD mothers had hypertension during pregnancy versus 12% in controls ( = 0.54) and >40% in comparative studies of chronic kidney disease in pregnancy. Eleven percent of births of ADTKD mothers were <37 weeks versus 0 in controls ( < 0.0001). Cesarean section occurred in 19% of pregnancies in affected women versus 38% of unaffected individuals ( = 0.06). Only 12% of babies required a neonatal intensive care unit stay.
Conclusions: ADTKD pregnancies had lower rates of hypertension during pregnancy versus other forms of chronic kidney disease, which may have contributed to good maternal and fetal outcomes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504889 | PMC |
| http://dx.doi.org/10.1177/1753495X221133150 | DOI Listing |
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