Wnt/β-catenin signaling is associated with epithelial-mesenchymal transformation (EMT), which serves an important role in hepatocellular carcinoma (HCC) invasion and metastasis. Frankincense and myrrh (FM) are antitumor agents commonly used in clinical practice. The present study aimed to investigate the effect and mechanism of water extract of FM on the progression of liver cancer cells. FM was applied to study its effects on HCC cell proliferation. Cell migration and invasion were evaluated by wound healing and Transwell assays. In addition, western blot was used to study the protein levels associated with EMT and Wnt/β-catenin signaling. The nuclear translocation of β-catenin was detected by immunofluorescence assay. A non-toxic dose of FM significantly inhibited invasion and metastasis of liver cancer cells. Furthermore, FM promoted expression of EMT marker E-cadherin, while decreasing expression of vimentin and N-cadherin. Finally, the protein and the nuclear staining levels of Disheveled 2 and β-catenin were both suppressed by water extract of FM. The water extract of FM inhibited the migration and invasion of liver cancer cells and inhibited EMT by suppressing activation of the Wnt/β-catenin signaling pathway.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502803 | PMC |
| http://dx.doi.org/10.3892/mco.2023.2673 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing the growth and essential oil components of Lavandula latifolia using Malva parviflora extract and humic acid as biostimulants in a field experiment.
Sci Rep
January 2025
Department of Floriculture, Ornamental Horticulture and Garden Design, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, 21545, Egypt.
Natural extracts as biostimulants have the potential to enhance the productivity and growth of many medicinal and aromatic plants. This study aimed to enhance the growth, and essential oil (EO) content, as well as composition of Lavandula latifolia Medik. by using Malva parviflora L.
View Article and Find Full Text PDFEco-friendly synthesis of CuO/g-C₃N₄/Fe₃O₄ nanocomposites for efficient magnetic micro-solid phase extraction (M-μ-SPE) of trace cadmium from food and water samples.
Food Chem
December 2024
Department of Chemistry, Faculty of Sciences, Erciyes University, Kayseri, Turkiye; Technology Research and Application Center (TAUM), Erciyes University, Kayseri, Turkiye; Turkish Academy of Sciences (TUBA), Cankaya, Ankara, Turkiye; Khazar University Nano BioAnalytical Chemistry Center (NBAC), Mahsati Str 41, AZ-1096 Baku, Azerbaijan.
In this study, a green synthesis method for synthesizing a novel nanocomposite (CuO/g-C₃N₄/Fe₃O₄) utilizing renewable dragon fruit peels as the primary raw material was developed. Hydrothermal and thermal decomposition techniques were used for nanocomposite synthesis. This nanocomposite was subsequently employed for the separation and preconcentration of Cd(II) from various environments, including food and water samples.
View Article and Find Full Text PDFUnbiased Metabolomic and Chemometric profiles of three Sargassum polycystum extracts using GCMS and LCMS/MS: content analysis, correlation analysis and molecular docking.
Food Chem
December 2024
Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam 13200 Kepala Batas, Penang, Malaysia. Electronic address:
Sargassum polycystum (S. polycystum) is a brown macroalga with a high phytochemical content, making it a nutritious and bioactive food source. However, information on factors contributing to health benefits, like antioxidants and cytotoxicity, is less explored for Malaysian S.
View Article and Find Full Text PDFAcoustic characteristics of three English semivowels /l, ɹ, w/ and vowels in young children with and without speech sound disorders.
J Commun Disord
December 2024
Department of Communication Sciences and Disorders, University of Wisconsin - Eau Claire, Human Sciences and Services 127, 239 Water Street, Eau Claire, Wisconsin 54703, United States. Electronic address:
Purpose: The aim of the current study is to examine if the relationship among three semivowel sounds (/l, ɹ, w/) and between the semivowel and the following vowel differs by children's overall speech proficiency, and if this relationship affects listeners' perceptual judgment of the liquid sounds (/l, ɹ/). The acoustic proximity among the three semivowel sounds and the acoustic characteristics of the following vowel sounds were examined by each child speaker's overall speech sound proficiency and their semivowel accuracy.
Methods: A total of 21 monolingual English-speaking children with and without speech sound disorders produced monosyllabic words that include target semivowel sounds in word-initial position in different vowel contexts.
Investigation and Characterization of Eco-Technological Synthesis of Spherical TiO Nanoparticles from Thalassia hemprichi and Analysis of Biomedical Properties.
Appl Biochem Biotechnol
January 2025
Ethnopharmacology and Algal Biotechnology Laboratory, Department of Botany, School of Life Sciences, Periyar University, Salem, Tamil Nadu, 636011, India.
In this present investigation, plant-mediated synthesis of titanium oxide (TiO) nanoparticles was synthesized from seagrass (Thalassia hemprichi) using the hot plate combustion method (HPCM). Synthesized TiO nanoparticles optical, functional, structural, and morphology properties were analyzed by UV-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). SEM analysis confirmed the spherical shape of the TiO nanoparticles were observed in various sizes, viz.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!